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Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits

, Universiteitssingel 60, 6229 ER Maastricht , The Netherlands 2 C. R. Bezzina Genome-wide association studies have shed light on the association between natural genetic variation and cardiovascular traits. However

Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study

Sudden cardiac death from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. This multifactorial, complex condition clusters in families, suggesting a substantial genetic cause. We carried out a genomewide association study (GWAS) for sudden cardiac death, in the AGNES (Arrhythmia Genetics in the Netherlands) population...

Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6

In this part of a series on founder mutations in the Netherlands, we review familial idiopathic ventricular fibrillation linked to the DPP6 gene. Familial idiopathic ventricular fibrillation determines an intriguing subset of the inheritable arrhythmia syndromes as there is no recognisable phenotype during cardiological investigation other than ventricular arrhythmias highly...

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium

. J. Aanhaanen B. P. Scicluna C. Annink M. J. B. van den Hoff A. A. M. Wilde M. W. Veldkamp J. M. T. de Bakker V. M. Christoffels C. R. Bezzina Heart Failure Research Center, Academic Medical Center