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Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study

Background & Objective Placental abruption, an ischemic placental disorder, complicates about 1 in 100 pregnancies, and is an important cause of maternal and perinatal morbidity and mortality worldwide. Metabolomics holds promise for improving the phenotyping, prediction and understanding of pathophysiologic mechanisms of complex clinical disorders including abruption. We sought to ...

Parker et al. Respond to “Preeclampsia Risk After Induced Abortion”

School of Public Health , Gothenburg , Sweden ( Mika Gissler); Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University , New York , New York (Cande V. Ananth); and ... Department of Epidemiol- ogy, Mailman School of Public Health, Columbia University , New York , New York (Cande V. Ananth). This work was supported by the National Institutes of Health (grant T32 HD052458 to

Invited Commentary: Is Prenatal Fasting During Ramadan Related to Adult Health Outcomes? A Novel and Important Question for Epidemiology

, College of Physicians and Surgeons, Columbia University Medical Center , New York , New York (Cande V. Ananth). Conflict of interest: none declared In this issue of the Journal, Van Ewijk et al. (Am J

An International Contrast of Rates of Placental Abruption: An Age-Period-Cohort Analysis

Background Although rare, placental abruption is implicated in disproportionately high rates of perinatal morbidity and mortality. Understanding geographic and temporal variations may provide insights into possible amenable factors of abruption. We examined abruption frequencies by maternal age, delivery year, and maternal birth cohorts over three decades across seven countries. ...

Economic and Survival Implications of Use of Electric Power Morcellation for Hysterectomy for Presumed Benign Gynecologic Disease

Background: Electric power morcellation during laparoscopic hysterectomy allows some women to undergo minimally invasive surgery but may disrupt underlying occult malignancies and increase the risk of tumor dissemination.

Relationship Between Surgical Oncologic Outcomes and Publically Reported Hospital Quality and Satisfaction Measures

Background: Hospital-level measures of patient satisfaction and quality are now reported publically by the Centers for Medicare and Medicaid Services. There are limited metrics specific to cancer patients. We examined whether publically reported hospital satisfaction and quality data were associated with surgical oncologic outcomes.

Placental Genome and Maternal-Placental Genetic Interactions: A Genome-Wide and Candidate Gene Association Study of Placental Abruption

Mahlet G. Tadesse 4 9 10 Bizu Gelaye 0 9 10 Sixto E. Sanchez 5 6 9 10 Manuel Salazar 7 9 10 Cande V. Ananth 8 9 10 Michelle A. Williams 0 9 10 Zhongxue Chen, Indiana University Bloomington, United States

Placental Abruption and Perinatal Mortality With Preterm Delivery as a Mediator: Disentangling Direct and Indirect Effects

Dentistry of New Jersey-Robert Wood Johnson Medical School , New Brunswick, New Jersey (Cande V. Ananth); and Departments of Epidemiology and of Biostatistics, Har- vard School of Public Health , Boston

Influence of Maternal Smoking on Placental Abruption in Successive Pregnancies: A Population-based Prospective Cohort Study in Sweden

study was supported by grants from the Karolinska Institutet. Dr. Cande V. Ananth was partially supported by a grant (HD038902) from the US National Institutes of Health. The authors thank Gunnar

Risk of placental abruption in relation to migraines and headaches

Background Migraine, a common chronic-intermittent disorder of idiopathic origin characterized by severe debilitating headaches and autonomic nervous system dysfunction, and placental abruption, the premature separation of the placenta, share many common pathophysiological characteristics. Moreover, endothelial dysfunction, platelet activation, hypercoagulation, and inflammation ...

Reexamining the effects of gestational age, fetal growth, and maternal smoking on neonatal mortality

Background Low birth weight (<2,500 g) is a strong predictor of infant mortality. Yet low birth weight, in isolation, is uninformative since it is comprised of two intertwined components: preterm delivery and reduced fetal growth. Through nonparametric logistic regression models, we examine the effects of gestational age, fetal growth, and maternal smoking on neonatal mortality. ...

Uteroplacental bleeding disorders during pregnancy: do missing paternal characteristics influence risk?

Background Several studies have assessed the risks of uteroplacental bleeding disorders in relation to maternal characteristics. The association between uteroplacental bleeding disorders and paternal characteristics, however, has received considerably less attention. Data on paternal demographics, notably race and age, from birth certificate data are becoming increasingly ...

Analysis of neonatal mortality:is standardizing for relative birth weight biased?

Background Infant mortality has traditionally been analyzed as a function of birth weight and birth weight-specific mortality. Often, however, when comparing two populations, the population with higher overall mortality has lower mortality at low birth weights and a reversed pattern at higher birth weights. Methods standardizing birth weight, such as the "relative birth weight", ...

A Proportional Hazards Model with Time-dependent Covariates and Time-varying Effects for Analysis of Fetal and Infant Death

Birth-weight- and gestational-age-specific perinatal mortality curves intersect when compared by race and maternal smoking. The authors propose a new measure to replace fetal and infant mortality and an analytic strategy to assess the effects of risk factors on this outcome. They used 1998 data for US Blacks and Whites. Age-specific post–last menstrual period (LMP) mortality rate ...

A parsimonious explanation for intersecting perinatal mortality curves: understanding the effects of race and of maternal smoking

Background Neonatal mortality rates among black infants are lower than neonatal mortality rates among white infants at birth weights <3000 g, whereas white infants have a survival advantage at higher birth weights. This finding is also observed when birth weight-specific neonatal mortality rates are compared between infants of smokers and non-smokers. We provide a parsimonious ...

Rates of Preterm Delivery among Black Women and White Women in the United States over Two Decades: An Age-Period-Cohort Analysis

The authors assessed the influence of age, period, and cohort effects on rates of preterm delivery in the United States. Rates of preterm delivery for singleton births (<37 weeks) in seven age groups (15–19, 20–24, …, 45–49 years), five periods (1975, 1980, 1985, 1990, 1995), and 11 maternal birth cohorts (1926–1930, 1931–1935, …, 1976–1980) were examined. Over the 20-year study ...

Placental Abruption among Singleton and Twin Births in the United States: Risk Factor Profiles

The authors performed a population-based epidemiologic study to evaluate and contrast risk factor profiles for placental abruption among singleton and twin gestations. Data were derived from linked US birth/infant death files for 1995 and 1996, comprising 7,465,858 singleton births and 193,266 twin births. The authors also evaluated effect modification between smoking and ...

Concordance among Measures of Pregnancy Outcome Based on Fetal Size and Duration of Gestation

Epidemiologic and clinical studies of pregnancy outcome often consider a variety of related, overlapping outcome measures. The overlap among these measures was analyzed using data from the Mount Sinai Hospital Perinatal Data Base, New York City, New York. A total of 52, 621 births from 1986 through 1996 were included, with information on gender, ethnicity, birth weight, and ...