gratefully acknowledged. Funding Carol Sinnott was supported by a research fellowship from the Health Research Board and the Health Service Executive (National SpR Academic Fellowship Programme NSAFP/2011/3
Multimorbidity, the presence of two or more chronic conditions, affects over 60 % of patients in primary care. Due to its association with polypharmacy, the development of interventions to optimise medication management in patients with multimorbidity is a priority. The Behaviour Change Wheel is a new approach for applying behavioural theory to intervention development. Here, we...
Background Multimorbidity, the presence of two or more chronic conditions, affects over 60 % of patients in primary care. Due to its association with polypharmacy, the development of interventions to optimise medication management in patients with multimorbidity is a priority. The Behaviour Change Wheel is a new approach for applying behavioural theory to intervention development...
supported by the Road Safety Authority of Ireland (grant 1.2016). Carol Sinnott is funded, through a clinical lectureship, by the National Institute for Health Research, School for Primary Care Research (NIHR ... PRISMA checklist. (DOC) S1 Table. Medline search strategy. (DOCX) S2 Table. Search dates for each database. (DOCX) Author Contributions Conceptualization: Carol Sinnott, Tony Foley. Data curation
For the majority of patients with multimorbidity, the prescription of multiple long-term medications (polypharmacy) is indicated. However, polypharmacy poses a risk of adverse drug events, drug interactions and excessive treatment burdens. To help general practitioners (GPs) conduct more comprehensive medication reviews for patients with multimorbidity, we developed the...
In November 2016, the ICH published a requirement for sponsors to develop a systematic, prioritised, risk-based approach to monitoring clinical trials. This approach is more commonly known as risk-based monitoring (RBM). However, recent evidence suggests that a ‘gold standard’, validated approach to RBM does not exist and it is unclear how sponsors will introduce RBM into their...