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Search: authors:"Cecília P. Popolin"

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Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype. The high rate of metastasis associated to the fact that these cells frequently display multidrug resistance, make the treatment of metastatic disease difficult. Development of antitumor metal-based drugs was started with the discovery of cisplatin, however, the severe side effects represent a...