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Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients

. Acknowledgments We are grateful to the patients who participated in this study. Author Contributions Data curation: Rohit Shetty, Anupam Sharma, Priyanka Chevour, Kamesh Dhamodaran, Chaitra Jayadev, Rudy M. M ... . A. Nuijts, Arkasubhra Ghosh, Jeyabalan Nallathambi. Formal analysis: Natasha Pahuja, Priyanka Chevour, Neeraja Padmajan, Kamesh Dhamodaran, Chaitra Jayadev, Rudy M. M. A. Nuijts, Arkasubhra Ghosh

The impact of dysfunctional tear films and optical aberrations on chronic migraine

Background Migraine is a multifactorial disorder with complex neuronal and vascular mechanisms that encompasses a wide clinical spectrum of symptoms, including ocular manifestations. Dry eye disease and dysfunction of ocular somatosensory pathways have been implicated in the pathogenesis. The current study investigates the association between a dysfunctional tear film and ocular...

Nanostructured scaffold as a determinant of stem cell fate

The functionality of stem cells is tightly regulated by cues from the niche, comprising both intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals are important components of extrinsic signals that dictate the stem cell properties. The materials used in the fabrication of scaffolds provide the chemical cues whereas the shape of the...

Two novel missense substitutions in the VSX1 gene: clinical and genetic analysis of families with Keratoconus from India

Background Visual system homeobox gene (VSX1) plays a major role in the early development of craniofacial and ocular tissues including cone opsin gene in the human retina. To date, few disease-causing mutations of VSX1 have been linked to familial and sporadic keratoconus (KC) in humans. In this study, we describe the clinical features and screening for VSX1 gene in families with...