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Search: authors:"Chang, Yu-Jung"

3 papers found.
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Acute exposure to DEHP metabolite, MEHP cause genotoxicity, mutagenesis and carcinogenicity in mammalian Chinese hamster ovary cells

Di-(2-ethylhexyl) phthalate (DEHP), the common plasticizer used in the production of polyvinyl chloride, can be converted to the more potent metabolite mono-ethylhexyl phthalate (MEHP). Epidemiological studies have shown an association with elevated induction of rat hepatic cancer and reproductive toxicity in response to MEHP exposure. However, the mechanism of genotoxicity and...

Mitogen-Activated Protein Kinases Potentiate Thyroid Hormone Receptor Transcriptional Activity by Stabilizing Its Protein

Transcriptional regulation of downstream gene expression by thyroid hormone (T3) is mediated by the thyroid hormone receptor (TR). T3 binding induces a complicated transition, where TR converts from a transcriptional repressor into a transcriptional activator and instigates downstream gene transcription. Binding of T3 to TR also induces the degradation of TR, resulting in...