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Evaluation of 99mTc-3PRGD2 integrin receptor imaging in hepatocellular carcinoma tumour-bearing mice: comparison with 18F-FDG metabolic imaging

Objective Our study was designed to explore the utility of 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfK)]2 (99mTc-3PRGD2) for the detection of hepatocellular carcinoma (HCC) and specifically to compare the diagnostic performance of 99mTc-3PRGD2 integrin receptor imaging and 2-18-fluoro-2-deoxy-d-glucose (18F-FDG) metabolic imaging in a nude mouse model. Methods 99mTc-3PRGD2 was synthesized ...

Mechanistic insights into the effect of imidazolium ionic liquid on lipid production by Geotrichum fermentans

Lou 0 Ning Li 0 Chao Huang Hong Wu 0 0 School of Food Science and Engineering, South China University of Technology , Room 409, Building 13, 381 Wushan Rd., Tianhe District, Guangzhou 510640 , China

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

Background The X-linked inhibitor of apoptosis protein (XIAP) is a well-known potent apoptosis suppressor and also participates in cancer cell biological behaviors, therefore attracting great attentions as a potential antineoplastic therapeutic target for past years. Anti-IAP therapy is reported to be closely related to epidermal growth factor receptor (EGFR) expression level. ...

Sensitivity and Specificity of Cardiac Tissue Discrimination Using Fiber-Optics Confocal Microscopy

Disturbances of the cardiac conduction system constitute a major risk after surgical repair of complex cases of congenital heart disease. Intraoperative identification of the conduction system may reduce the incidence of these disturbances. We previously developed an approach to identify cardiac tissue types using fiber-optics confocal microscopy and extracellular fluorophores. ...

Retinal vein occlusion in retinal racemose hemangioma: a case report and literature review of ocular complications in this rare retinal vascular disorder

Backgroud Retinal racemose hemangioma (RRH) is a rare congenital disorder that often co-occurs with other ocular complications. In this study, we present a case of RRH complicated with retinal vein obstruction in three branches and provide a review of ocular complications and associations with RRH. Case presentation One case of RRH is presented. Fundus examination, fluorescein ...

Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia

authors read and approved the final manuscript. Acknowledgements This work was supported by the Natural Science Foundation of Jiangsu Province to Dr Chao Huang (No. BK20141240), the National Natural ... Science Foundation of China Dr Chao Huang (No. 81102428), and the Priority Academic Program Development of Jiangsu Higher Education Institutions. 1. O'Connor DM , O'Brien T. Nitric oxide synthase gene

Imbalances in Mobilization and Activation of Pro-Inflammatory and Vascular Reparative Bone Marrow-Derived Cells in Diabetic Retinopathy

Diabetic retinopathy is a sight-threatening complication of diabetes, affecting 65% of patients after 10 years of the disease. Diabetic metabolic insult leads to chronic low-grade inflammation, retinal endothelial cell loss and inadequate vascular repair. This is partly due to bone marrow (BM) pathology leading to increased activity of BM-derived pro-inflammatory monocytes and ...

Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population

Hypothesis: Polymorphisms in angiotensin II type-1/2 receptor genes (AGTR1/AGTR2) may be involved in the pathogenesis of primary aldosteronism. The present study aims to reveal some loci susceptible to the disease on the genes in a group of Chinese Han nationality.

Levee failure mechanisms during the extreme rainfall event: a case study in Southern Taiwan

Extreme weather has recently caused many disasters worldwide. In August 8, 2009, Southern Taiwan suffered from serious floods during Typhoon Morakot. In this extreme rainfall event, the Chiuliao first levee in the Laonong River basin experienced catastrophic failure. Therefore, this study focuses on the levee failure mechanisms based on variations in levee water levels. ...

The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

Gui-Zhen Wang Xin Cheng Bo Zhou Zhe-Sheng Wen Yun-Chao Huang Hao-Bin Chen Gao-Feng Li Zhi-Liang Huang Yong-Chun Zhou Lin Feng Ming-Ming Wei Li-Wei Qu Yi Cao Guang-Biao Zhou 0 Department of Thoracic

2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice

reduces the activation of IkB-a-NF-kB pathway in liver. - Funding: This work was supported by the National Natural Science Foundation of China to Dr. Chao Huang (No. 81102428) and also supported by a

Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection

Chondroitin sulfate proteoglycans (CSPGs) are glial scar-associated molecules considered axonal regeneration inhibitors and can be digested by chondroitinase ABC (ChABC) to promote axonal regeneration after spinal cord injury (SCI). We previously demonstrated that intrathecal delivery of low-dose ChABC (1 U) in the acute stage of SCI promoted axonal regrowth and functional ...

Glioma-Derived ADAM10 Induces Regulatory B Cells to Suppress CD8+ T Cells

0 Zhen-chao Huang 0 Ying Guo 0 Roberto Furlan, San Raffaele Scientific Institute, Italy 0 Department of neurosurgery, Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China CD8+ T

SKF83959, an Agonist of Phosphatidylinositol-Linked D1-Like Receptors, Promotes ERK1/2 Activation and Cell Migration in Cultured Rat Astrocytes

Science Foundation of China for Postdoctors (No. 20110490115) and the National Natural Science Foundation of China to Dr. Chao Huang (No. 81102428). Competing Interests: The authors have declared that no

Insights from systems pharmacology into cardiovascular drug discovery and therapy

Background Given the complex nature of cardiovascular disease (CVD), information derived from a systems-level will allow us to fully interrogate features of CVD to better understand disease pathogenesis and to identify new drug targets. Results Here, we describe a systematic assessment of the multi-layer interactions underlying cardiovascular drugs, targets, genes and disorders to ...

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Background Modern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate the drug discovery from herbal medicines, an efficient systems pharmacology platform that represents ideal information ...

TSG (2,3,4’ ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia

Chao Huang 0 Yuzhe Wang 0 Jia Wang Wenjuan Yao Xiangfan Chen Wei Zhang 0 Equal contributors Department of Pharmacology, School of Medicine, Nantong University , 19 Qixiu Road, Nantong 226001, Jiangsu

The Reduced Plastid-Encoded Polymerase-Dependent Plastid Gene Expression Leads to the Delayed Greening of the Arabidopsis fln2 Mutant

In Arabidopsis leaf coloration mutants, the delayed greening phenomenon is common. Nonetheless, the mechanism remains largely elusive. Here, a delayed greening mutant fln2–4 of FLN2 (Fructokinase-Like Protein2) was studied. FLN2 is one component of Transcriptionally Active Chromosome (TAC) complex which is thought to contain the complete plastid-encoded polymerase (PEP). fln2–4 ...