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Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1 overexpression on fetal atrial septal development. An inducible double transgenic (DTg) mouse model...

Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1 overexpression on fetal atrial septal development. An inducible double transgenic (DTg) mouse model...

Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice

) Acknowledgments We thank Richard Tu for technical assistance on the animal surgical model. Author Contributions Conceptualization: Che-Chung Yeh, Yanying Fan, Paul C. Simpson, Michael J. Mann. Data curation ... : Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang. Formal analysis: Che-Chung Yeh, Yanying Fan, Paul C. Simpson, Michael J. Mann. Funding acquisition: Michael J. Mann. Investigation: Yanying Fan

Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells

, Che-Chung Yeh, Gabriele Ludewig, Edward J Kasarskis & Daret K St.ClairDepartment of Neurology, University of Kentucky, Lexington, Kentucky 40536-0305, USAYong Xu, Anuradha Krishnan, X Steven Wan ... for X Steven Wan in:Nature Research journals • PubMed • Google ScholarSearch for Hideyuki Majima in:Nature Research journals • PubMed • Google ScholarSearch for Che-Chung Yeh in:Nature Research journals