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Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites

Leslie Cruz 1 Daria Mochly-Rosen 1 0 Equal contributors Department of Chemical and Systems Biology, Stanford University, School of Medicine , Stanford, CA 94305-5174 , USA 1 Aishwarya Nene and Che-Hong ... Chen are 1st-coauthors of this publication Background: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from

PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation

The ALDH2 gene encodes the mitochondrial aldehyde dehydrogenase 2 (ALDH2), a critical enzyme involved in ethanol clearance through acetaldehyde metabolism. ALDH2 also catalyzes the metabolism of other bioreactive aldehydes, including propionaldehyde, butyraldehyde, and 4-hydroxykenals (4-HNE). Increased levels of 4-HNE in adipose tissue positively correlate with obesity and insulin ...

Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

-Hong Chen Eric R. Gross Daria Mochly-Rosen Yasuki Kihara 0 0 Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical & Health Sciences , 1-2-3 Kasumi, Minami-ku

Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

-Hong Chen Eric R. Gross Daria Mochly-Rosen Yasuki Kihara 0 0 Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical & Health Sciences , 1-2-3 Kasumi, Minami-ku

Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: Gene-environmental interaction with alcohol consumption

Chang 0 Yen-Feng Chiu I-Te Lee Low-Tone Ho Yi-Jen Hung Chao A Hsiung Thomas Quertermous Timothy Donlon Wei-Jei Lee Po-Chu Lee Che-Hong Chen Daria Mochly-Rosen Lee-Ming Chuang 0 1 0 Department of Internal