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Effects of magnesium and ionic strength on the diffusion and charge properties of several single tRNA species

Kee Woo Rhee 1 Russell O.Pottst 1 Chun-Chen Wang" Maurille J.Fournier Norman C. Ford 0 Biochemistry, University of Massachusetts , Amherst, MA 01003 , USA 1 Present addresses: K.W.R.-Biophysics

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Jocelyne Chiquette Laima Tihomirova Tara M. Friebel Bjarni A. Agnarsson Karen H. Lu Flavio Lejbkowicz Paul A. James Per Hall Alison M. Dunning Daniel Tessier Julie Cunningham Susan L. Slager Chen Wang Steven ... Damiola, Catherine Houghton, Alex Murray, Jan Lubinski, Conxi Lazaro, Christine Walsh, Chen Wang, Jenny Lester, Huw Dorkins, Helmut Deissler, Ian Campbell, Isabelle Coupier, Judith Balma na, Joan Brunet

The observation of the local ordering characteristics of spermidine-condensed DNA: Atomic force microscopy and polarizing microscopy studies

Condensation of DNA by multivalent cations can provide useful insights into the physical factors governing the folding and packaging of DNA in vivo. In this work, local ordered structures of spermidine-DNA complexes prepared from different DNA concentrations have been examined by using atomic force microscopy (AFM) and polarizing microscopy (PM). Two types (I and II) of DNA...

A convenient method of aligning large DNA molecules on bare mica surfaces for atomic force microscopy

Large DNA molecules remain difficult to be imaged by atomic force microscopy (AFM) because of the tendency of aggregation. A method is described to align long DNA fibers in a single direction on unmodified mica to facilitate AFM studies. The clear background, minimal overstretching, high reproducibility and convenience of this aligning procedure make it useful for physical...

Antiviral Therapy and Outcomes of Patients with Pneumonia Caused by Influenza A Pandemic (H1N1) Virus

Chen Wei-bo Du Xi-xin Yan Zong-an Liang Wei Zhang Chang-le Zhang Wei Chen Cai-ping Guo Xun-liang Jiang Ming Yang Guang-ming Deng Kai-jiang Yu Ke Hu Qi Zou Lan-juan Li Chen Wang for the National Influenza

Inherited Variants in Regulatory T Cell Genes and Outcome of Ovarian Cancer

Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a growing body of data supports the existence of inherited prognostic factors. However, the role of inherited variants in genes...

Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke

Introduction Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol-lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients. Methods This prospective study evaluated 172 patients with acute ischemic stroke divided in two groups: patients...

Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive auditory neuropathy

Background Mutations in OTOF gene, encoding otoferlin, cause DFNB9 deafness and non-syndromic auditory neuropathy (AN). The aim of this study is to identify OTOF mutations in Chinese patients with non-syndromic auditory neuropathy. Methods 73 unrelated Chinese Han patients with AN, including one case of temperature sensitive non-syndromic auditory neuropathy (TS-NSRAN) and 92...

Delayed minocycline but not delayed mild hypothermia protects against embolic stroke

Background Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined. Methods Focal ischemic injury was induced by embolizing a preformed clot into the middle cerebral...

Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room

Chia-Te Kung Sheng-Yuan Hsiao Tsung-Cheng Tsai Chih-Min Su Wen-Neng Chang 0 Chi-Ren Huang 0 Hung-Chen Wang Wei-Che Lin Hsueh-Wen Chang Yu-Jun Lin Ben-Chung Cheng Ben Yu-Jih Su Nai-Wen Tsai 0 1 Cheng

Predictors and outcomes of shunt-dependent hydrocephalus in patients with aneurysmal sub-arachnoid hemorrhage

BackgroundHydrocephalus following spontaneous aneurysmal sub-arachnoid hemorrhage (SAH) is often associated with unfavorable outcome. This study aimed to determine the potential risk factors and outcomes of shunt-dependent hydrocephalus in aneurysmal SAH patients but without hydrocephalus upon arrival at the hospital.MethodsOne hundred and sixty-eight aneurysmal SAH patients were...

Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more...

Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes

Background This study aimed to analyze the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes of bacterial brain abscess in patients with nasopharyngeal carcinoma (NPC) following radiotherapy. Methods NPC patients with bacterial brain abscess were evaluated. Their clinical data were collected over a 22-year period. For comparison, the...

Abscisic acid regulates TSRF1-mediated resistance to Ralstonia solanacearum by modifying the expression of GCC box-containing genes in tobacco

Although recent studies have established a significant regulatory role for abscisic acid (ABA) and ethylene response factor (ERF) proteins in plant pathogen resistance, it is not clear whether and how ABA performs this role. Previously, it was reported that an ERF protein, TSRF1, activates the expression of GCC box-containing genes and significantly enhances the resistance to...

Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel

4 Devin C. Koestler 6 Brooke L. Fridley 5 Kimberly R. Kalli 2 Sebastian M. Armasu 4 Melissa C. Larson 4 Chen Wang 4 Stacey J. Winham 4 Robert A. Vierkant 4 David N. Rider 4 Matthew S. Block 0 Brandy

CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration

BackgroundEndothelial E-selectin has been shown to play a pivotal role in mediating cell–cell interactions between breast cancer cells and endothelial monolayers during tumor cell metastasis. However, the counterreceptor for E-selectin and its role in mediating breast cancer cell transendothelial migration remain unknown.Methodology/Principal FindingsBy assessing migration of...

NEURO-ONCOLOGY IN DEVELOPING COUNTRIES

INTRODUCTION: Using ventricoluperitoneal shunt before the resection of pediatric posterior fossa brain tumors, presenting with hydrocephalus used to be common practice, but most centers now are abandoning this policy due to the complications associated with the shunt. MATERIAL AND METHODS: We report retrospectively on the short term outcome of posterior fossa brain tumour in...

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population

Background Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism. Methods/Principal Findings Twenty-one single nucleotide polymorphisms (SNPs) from fourteen loci...

Efficacy and safety of 2-hour urokinase regime in acute pulmonary embolism: a randomized controlled trial

Thromboembolism(VTE) Study Group for their great contributions to this study. The members of the study group were as follows: Steering Committee--Chen Wang, Xiansheng Cheng, Xinzhi Weng, Weixuan Lu, Quanying He ... , Yiming Zhao, Binrong Ma, Nanshan Zhong; Independent Central Adjudication Committee--Xiansheng Cheng, Ruping Dai, Youmin Guo, Tie Wang, Weixuan Lu, Quanying He, Yiming Zhao, Chen Wang; Data and Coordinating