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Exotic Higgs decay \(h\rightarrow \phi \phi \rightarrow 4b\) at the LHeC

We study the exotic decay of the 125 GeV Higgs boson (h) into a pair of light spin-0 particles (\(\phi \)) which subsequently decay and result in a 4b final state. This channel is well motivated in models with an extended Higgs sector. Instead of searching at the Large Hadron Collider (LHC) and the high luminosity LHC (HL-LHC) which are beset by large standard model (SM) ...

Elastic restricted Boltzmann machines for cancer data analysis

61472205), and China’s Youth 1000-Talent Program, the Beijing Advanced Innovation Center for Structural Biology. COMPLIANCE WITH ETHICS GUIDELINES The authors Sai Zhang, Muxuan Liang, Zhongjun Zhou, Chen ... Zhang, Ning Chen, Ting Chen and Jianyang Zeng declare that they have no conflict of interests. This article does not contain any studies with human or animal subjects performed by any of the authors. 1

An enhanced vector-free allele exchange (VFAE) mutagenesis protocol for genome editing in a wide range of bacterial species

Vector-free allele exchange (VFAE) is a newly developed protocol for genome editing in Pseudomonas species. Although several parameters have been determined to optimize the procedures for obtaining a stable and high-frequency mutation, numerous false-positive clones still appear on the plate, which increases the difficulty of finding the desired mutants. It has also not been ...

A High-Efficiency Si Nanowire Array/Perovskite Hybrid Solar Cell

A low-cost Si nanowire array/perovskite hybrid solar cell is proposed and simulated. The solar cell consists of a Si p-i-n nanowire array filled with CH3NH3PbI3, in which both the nanowires and perovskite absorb the incident light while the nanowires act as the channels for transporting photo-generated electrons and holes. The hybrid structure has a high absorption efficiency in a ...

Selection of reference genes from Shiraia bambusicola for RT-qPCR analysis under different culturing conditions

Stable reference genes are necessary to analyse quantitative real-time reverse transcription PCR (qRT-PCR) data and determine the reliability of the final results. For further studies of the valuable fungus Shiraia bambusicola, the identification of suitable reference genes has become increasingly urgent. In this study, three conventional reference genes and nine novel candidates ...

The superior fault tolerance of artificial neural network training with a fault/noise injection-based genetic algorithm

Chen Zhang declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by the any of the authors. ð2Þ OPEN ACCESS AUTHOR

Substance Use and Psychosocial Status among People Living with HIV/AIDS Who Encountered HIV Stigma in China: Stratified Analyses by Socio-Economic Status

This study examined whether the impact of HIV stigma on psychosocial status and substance use among people living with HIV/AIDS (PLWHA) differed by their socio-economic status (SES) in a Chinese setting. A total of 2,987 PLWHA were recruited from 12 sites with the highest number of cumulative HIV incidence in Guangxi, China. Participants were asked to provide information regarding ...

Low health literacy and psychological symptoms potentially increase the risks of non-suicidal self-injury in Chinese middle school students

Background Low health literacy (HL) has been known to be involved in various risk behaviors and mental disorder among adolescent. The purpose of this study was to examine the independent and interactive association between HL and self-reported mental health with non-suicidal self-injury (NSSI) in Chinese middle school students. Methods Twenty five thousand three hundred ...

Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression

Cardiovascular diseases are risk factors for depression in humans. We recently proposed that σ1 receptor (σ1R) stimulation rescued cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC) in mice. Importantly, σ1R stimulation reportedly ameliorates depression-like behaviors in rodents. Thus, we hypothesized that impaired σ1R activity in brain triggers ...

Issues and solutions of China’s generation resource utilization based on sustainable development

Chen ZHANG 0 1 0 & Kangting CHEN 1 School of Economics and Management, North China Electric Power University , Beijing , China With the rapid development of its national economy, China has become a ... the Ph.D. degree in economic management in North China Electric Power University, Beijing, China. His research interests include power system optimization and power market. Chen ZHANG received the B.S

Packing sulfur into carbon framework for high volumetric performance lithium-sulfur batteries

this contribution and Zhang C was mainly responsible for preparing the initial manuscript. Conflict of interest The authors declare that they have no conflict of interest. Chen Zhang received his BSc

The complex genetics in autism spectrum disorders

Autism spectrum disorders (ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants (CNVs), linkage ...

A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53

p53 function is frequently inhibited in cancer either through mutations or by increased degradation via MDM2 and/or E6AP E3-ubiquitin ligases. Most agents that restore p53 expression act by binding MDM2 or E6AP to prevent p53 degradation. However, fewer compounds directly bind to and activate p53. Here, we identified compounds that shared a core structure that bound p53, caused ...

Experimental transmission of Babesia microti by Rhipicephalus haemaphysaloides

Background Human babesiosis is considered an emerging threat in China. Dozens of human infections with Babesia microti have been reported recently, especially in southern China. However, the transmission vectors of this parasite in these areas are not well understood. Rhipicephalus haemaphysaloides, which is one of the dominant tick species in southern China, is a major vector of ...

Identification of lumbar disc disease hallmarks: a large cross-sectional study

Background Lumbar disc disease has a disabling impact on global people with heavy burden on society, mainly consisting of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH). The recently released lumbar disc nomenclature version 2.0 deepens our understandings on the diseases. Consequently, there is an urgent need to clarify the occurrence and distribution features of ...

Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of gastroenteritis in cattle and humans. Dendritic cells (DC) and macrophages (Mø) are major players in early immunity to Salmonella, and their response could influence the course of infection. Therefore, the global transcriptional response of bovine monocyte-derived DC and Mø to stimulation with live and ...

RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription

Background ALL1-fused from chromosome 1q (AF1q), originally considered as an oncogenic factor, has been implicated in neuronal development; however, its upstream regulatory mechanisms in neural system remained elusive. Results Our study showed that REST (RE1 silencing transcription factor), a key transcription factor in neurodevelopment, could down-regulate the gene expression of ...

Stable Asymptotically Free Extensions (SAFEs) of the Standard Model

We consider possible extensions of the standard model that are not only completely asymptotically free, but are such that the UV fixed point is completely UV attractive. All couplings flow towards a set of fixed ratios in the UV. Motivated by low scale unification, semi-simple gauge groups with elementary scalars in various representations are explored. The simplest model is a ...

Next Generation Sequencing-Based Investigation of Potential Patient-to-Patient Hepatitis C Virus Transmission during Hemodialytic Treatment

We investigated potential patient-to-patient transmission of hepatitis C virus (HCV) in two hemodialysis centers in Beijing, China. Approximately 8.25% (32/388) hemodialysis patients were HCV antibody positive, and 4.90% (19/388) were HCV RNA-positive, which consisted of 2a genotype (1/19) and 1b genotypes (18/19). Using next generation sequencing (NGS) approach, MiSeq platform, we ...

Stigma against People Living with HIV/AIDS in China: Does the Route of Infection Matter?

In the current study, we tested the hypothesis that people who contracted HIV from “blameless” routes (e.g., blood transfusion, sex with stable partners) are less stigmatized compared to people who contracted HIV from “blamable” routes (e.g., injection drug use, sex with sex workers). A cross-sectional study was conducted among 2,987 participants in Guangxi province, China, between ...