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An enhanced vector-free allele exchange (VFAE) mutagenesis protocol for genome editing in a wide range of bacterial species

Vector-free allele exchange (VFAE) is a newly developed protocol for genome editing in Pseudomonas species. Although several parameters have been determined to optimize the procedures for obtaining a stable and high-frequency mutation, numerous false-positive clones still appear on the plate, which increases the difficulty of finding the desired mutants. It has also not been ...

Elastic restricted Boltzmann machines for cancer data analysis

61472205), and China’s Youth 1000-Talent Program, the Beijing Advanced Innovation Center for Structural Biology. COMPLIANCE WITH ETHICS GUIDELINES The authors Sai Zhang, Muxuan Liang, Zhongjun Zhou, Chen ... Zhang, Ning Chen, Ting Chen and Jianyang Zeng declare that they have no conflict of interests. This article does not contain any studies with human or animal subjects performed by any of the authors. 1

A High-Efficiency Si Nanowire Array/Perovskite Hybrid Solar Cell

A low-cost Si nanowire array/perovskite hybrid solar cell is proposed and simulated. The solar cell consists of a Si p-i-n nanowire array filled with CH3NH3PbI3, in which both the nanowires and perovskite absorb the incident light while the nanowires act as the channels for transporting photo-generated electrons and holes. The hybrid structure has a high absorption efficiency in a ...

Selection of reference genes from Shiraia bambusicola for RT-qPCR analysis under different culturing conditions

Stable reference genes are necessary to analyse quantitative real-time reverse transcription PCR (qRT-PCR) data and determine the reliability of the final results. For further studies of the valuable fungus Shiraia bambusicola, the identification of suitable reference genes has become increasingly urgent. In this study, three conventional reference genes and nine novel candidates ...

The superior fault tolerance of artificial neural network training with a fault/noise injection-based genetic algorithm

Chen Zhang declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by the any of the authors. ð2Þ OPEN ACCESS AUTHOR

Low health literacy and psychological symptoms potentially increase the risks of non-suicidal self-injury in Chinese middle school students

Background Low health literacy (HL) has been known to be involved in various risk behaviors and mental disorder among adolescent. The purpose of this study was to examine the independent and interactive association between HL and self-reported mental health with non-suicidal self-injury (NSSI) in Chinese middle school students. Methods Twenty five thousand three hundred ...

Issues and solutions of China’s generation resource utilization based on sustainable development

Chen ZHANG 0 1 0 & Kangting CHEN 1 School of Economics and Management, North China Electric Power University , Beijing , China With the rapid development of its national economy, China has become a ... the Ph.D. degree in economic management in North China Electric Power University, Beijing, China. His research interests include power system optimization and power market. Chen ZHANG received the B.S

Packing sulfur into carbon framework for high volumetric performance lithium-sulfur batteries

this contribution and Zhang C was mainly responsible for preparing the initial manuscript. Conflict of interest The authors declare that they have no conflict of interest. Chen Zhang received his BSc

The complex genetics in autism spectrum disorders

Autism spectrum disorders (ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants (CNVs), linkage ...

Identification of lumbar disc disease hallmarks: a large cross-sectional study

Background Lumbar disc disease has a disabling impact on global people with heavy burden on society, mainly consisting of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH). The recently released lumbar disc nomenclature version 2.0 deepens our understandings on the diseases. Consequently, there is an urgent need to clarify the occurrence and distribution features of ...

Experimental transmission of Babesia microti by Rhipicephalus haemaphysaloides

Background Human babesiosis is considered an emerging threat in China. Dozens of human infections with Babesia microti have been reported recently, especially in southern China. However, the transmission vectors of this parasite in these areas are not well understood. Rhipicephalus haemaphysaloides, which is one of the dominant tick species in southern China, is a major vector of ...

Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major cause of gastroenteritis in cattle and humans. Dendritic cells (DC) and macrophages (Mø) are major players in early immunity to Salmonella, and their response could influence the course of infection. Therefore, the global transcriptional response of bovine monocyte-derived DC and Mø to stimulation with live and ...

RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription

Background ALL1-fused from chromosome 1q (AF1q), originally considered as an oncogenic factor, has been implicated in neuronal development; however, its upstream regulatory mechanisms in neural system remained elusive. Results Our study showed that REST (RE1 silencing transcription factor), a key transcription factor in neurodevelopment, could down-regulate the gene expression of ...

Next Generation Sequencing-Based Investigation of Potential Patient-to-Patient Hepatitis C Virus Transmission during Hemodialytic Treatment

We investigated potential patient-to-patient transmission of hepatitis C virus (HCV) in two hemodialysis centers in Beijing, China. Approximately 8.25% (32/388) hemodialysis patients were HCV antibody positive, and 4.90% (19/388) were HCV RNA-positive, which consisted of 2a genotype (1/19) and 1b genotypes (18/19). Using next generation sequencing (NGS) approach, MiSeq platform, we ...

Stable Asymptotically Free Extensions (SAFEs) of the Standard Model

We consider possible extensions of the standard model that are not only completely asymptotically free, but are such that the UV fixed point is completely UV attractive. All couplings flow towards a set of fixed ratios in the UV. Motivated by low scale unification, semi-simple gauge groups with elementary scalars in various representations are explored. The simplest model is a ...

Human immunodeficiency virus, syphilis and hepatitis C virus prevalence trends among cross-border migrant Vietnamese female sex workers in Guangxi, China

Background Global literature indicates the burden of human immunodeficiency virus (HIV), syphilis and hepatitis C virus (HCV) has disproportionately affected cross-border migrant female sex workers (FSW). However, few studies reported the HIV risk among Vietnamese FSW at borderline areas in China. We examined five consecutive years of HIV, syphilis, and HCV prevalence and ...

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

GUIDENLINES Jintao Bao, Liangjun Zheng, Qi Zhang, Xinya Li, Xuefei Zhang, Zeyang Li, Xue Bai, Zhong Zhang, Wei Huo, Xuyang Zhao, Shujiang Shang, Qingsong Wang, Chen Zhang, and Jianguo Ji declare that they have

The influence of body composition on renal function in patients with coronary artery disease and its prognostic significance: a retrospective cohort study

Objective We try to analyse the effect of renal functions on death in CAD patients with different body compositions. Methods A retrospective analysis was conducted in 2989 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into two categories: basically preserved renal function (PRF) (eGFR ≥60 ml/min) and obviously reduced renal function ...

Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis

Background RPS15A is a ribosome protein that is highly conserved in many organisms from yeast to human. A number of studies implied its role in promoting cancer cell growth. Methods Here, we firstly conducted RPS15A gene expression analysis in brain cancer using Oncomine database and found RPS15A was remarkably overexpressed in glioblastoma (GBM) compared with that in normal ...

A photoacoustic image reconstruction method using total variation and nonconvex optimization

Background In photoacoustic imaging (PAI), the reduction of scanning time is a major concern for PAI in practice. A popular strategy is to reconstruct the image from the sparse-view sampling data. However, the insufficient data leads to reconstruction quality deteriorating. Therefore, it is very important to enhance the quality of the sparse-view reconstructed images. Method In ...