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A hybrid outdoor localization scheme with high-position accuracy and low-power consumption

As mobile devices, such as smart phones, become more and more popular, localization based on mobile devices has gained much attention in both the academia and industry. Although global positioning system (GPS) has been widely deployed in many fields, it has several disadvantages such as consuming too much power and requiring the line of sight to satellites. Cellular network-based ...

The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer

The treatment paradigm of non-small cell lung cancer (NSCLC) has evolved into oncogene-directed precision medicine. Identifying actionable genomic alterations is the initial step towards precision medicine. An important scientific progress in molecular profiling of NSCLC over the past decade is the shift from the traditional piecemeal fashion to massively parallel sequencing with ...

Exotic Higgs decay \(h\rightarrow \phi \phi \rightarrow 4b\) at the LHeC

We study the exotic decay of the 125 GeV Higgs boson (h) into a pair of light spin-0 particles (\(\phi \)) which subsequently decay and result in a 4b final state. This channel is well motivated in models with an extended Higgs sector. Instead of searching at the Large Hadron Collider (LHC) and the high luminosity LHC (HL-LHC) which are beset by large standard model (SM) ...

The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells

Bone cancer pain (BCP) severely compromises the quality of life, while current treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide (T10), a substance with considerable anti-tumor efficacies on BCP, and investigated the underlying mechanisms targeting the spinal dorsal horn (SDH). Intratibial inoculation of Walker 256 mammary gland ...

Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population

Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have ...

Incidence, clinical characteristics, and outcome of interstitial pneumonia in patients with lymphoma

Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP was observed in 106 patients. Of these, 23 patients were excluded ...

Elastic restricted Boltzmann machines for cancer data analysis

61472205), and China’s Youth 1000-Talent Program, the Beijing Advanced Innovation Center for Structural Biology. COMPLIANCE WITH ETHICS GUIDELINES The authors Sai Zhang, Muxuan Liang, Zhongjun Zhou, Chen ... Zhang, Ning Chen, Ting Chen and Jianyang Zeng declare that they have no conflict of interests. This article does not contain any studies with human or animal subjects performed by any of the authors. 1

A High-Efficiency Si Nanowire Array/Perovskite Hybrid Solar Cell

A low-cost Si nanowire array/perovskite hybrid solar cell is proposed and simulated. The solar cell consists of a Si p-i-n nanowire array filled with CH3NH3PbI3, in which both the nanowires and perovskite absorb the incident light while the nanowires act as the channels for transporting photo-generated electrons and holes. The hybrid structure has a high absorption efficiency in a ...

Selection of reference genes from Shiraia bambusicola for RT-qPCR analysis under different culturing conditions

Stable reference genes are necessary to analyse quantitative real-time reverse transcription PCR (qRT-PCR) data and determine the reliability of the final results. For further studies of the valuable fungus Shiraia bambusicola, the identification of suitable reference genes has become increasingly urgent. In this study, three conventional reference genes and nine novel candidates ...

A Flexible and Efficient Output File Format for Grain-Scale Multiphysics Simulations

Modern high-performing structural materials gain their excellent properties from the complex interactions of various constituent phases, grains, and subgrain structures that are present in their microstructure. To further understand and improve their properties, simulations need to take into account multiple aspects in addition to the composite nature. Crystal plasticity ...

An enhanced vector-free allele exchange (VFAE) mutagenesis protocol for genome editing in a wide range of bacterial species

Vector-free allele exchange (VFAE) is a newly developed protocol for genome editing in Pseudomonas species. Although several parameters have been determined to optimize the procedures for obtaining a stable and high-frequency mutation, numerous false-positive clones still appear on the plate, which increases the difficulty of finding the desired mutants. It has also not been ...

The superior fault tolerance of artificial neural network training with a fault/noise injection-based genetic algorithm

, exclusive OR. COMPLIANCE WITH ETHICS GUIDELINES Feng Su, Peijiang Yuan, Yangzhen Wang and Chen Zhang declare that they have no conflict of interest. This article does not contain any studies with human or

Substance Use and Psychosocial Status among People Living with HIV/AIDS Who Encountered HIV Stigma in China: Stratified Analyses by Socio-Economic Status

This study examined whether the impact of HIV stigma on psychosocial status and substance use among people living with HIV/AIDS (PLWHA) differed by their socio-economic status (SES) in a Chinese setting. A total of 2,987 PLWHA were recruited from 12 sites with the highest number of cumulative HIV incidence in Guangxi, China. Participants were asked to provide information regarding ...

Packing sulfur into carbon framework for high volumetric performance lithium-sulfur batteries

this contribution and Zhang C was mainly responsible for preparing the initial manuscript. Conflict of interest The authors declare that they have no conflict of interest. Chen Zhang received his BSc

Issues and solutions of China’s generation resource utilization based on sustainable development

Chen ZHANG 0 1 0 & Kangting CHEN 1 School of Economics and Management, North China Electric Power University , Beijing , China With the rapid development of its national economy, China has become a ... the Ph.D. degree in economic management in North China Electric Power University, Beijing, China. His research interests include power system optimization and power market. Chen ZHANG received the B.S

Low health literacy and psychological symptoms potentially increase the risks of non-suicidal self-injury in Chinese middle school students

Background Low health literacy (HL) has been known to be involved in various risk behaviors and mental disorder among adolescent. The purpose of this study was to examine the independent and interactive association between HL and self-reported mental health with non-suicidal self-injury (NSSI) in Chinese middle school students. Methods Twenty five thousand three hundred ...

The complex genetics in autism spectrum disorders

Autism spectrum disorders (ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants (CNVs), linkage ...

CRISPR/Cas9 mediated chicken Stra8 gene knockout and inhibition of male germ cell differentiation

An efficient genome editing approach had been established to construct the stable transgenic cell lines in the domestic chicken (Gallus gallus domesticus) at present. Our objectives were to investigate gene function in the differentiation process of chicken embryonic stem cells (ESCs) into spermatogonial stem cells(SSCs). Three guides RNA (gRNAs) were designed to knockout the Stra8 ...

Comparison of Electric- and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso

Myocardial ventricular ischemia arises from a lack of blood supply to the heart, which may cause abnormal repolarization and excitation wave conduction patterns in the tissue, leading to cardiac arrhythmias and even sudden death. Current diagnosis of cardiac ischemia by the 12-lead electrocardiogram (ECG) has limitations as they are insensitive in many cases and may show ...

A DNA Binding Protein Is Required for Viral Replication and Transcription in Bombyx mori Nucleopolyhedrovirus

A DNA-binding protein (DBP) [GenBank accession number: M63416] of Bombyx mori nuclear polyhedrosis virus (BmNPV) has been reported to be a regulatory factor in BmNPV, but its detailed functions remain unknown. In order to study the regulatory mechanism of DBP on viral proliferation, genome replication, and gene transcription, a BmNPV dbp gene knockout virus dbp-ko-Bacmid was ...