33 papers found.

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We consider the relation between SYK-like models and vector models by studying a toy model where a tensor field is coupled with a vector field. By integrating out the tensor field, the toy model reduces to the Gross-Neveu model in 1 dimension. On the other hand, a certain perturbation can be turned on and the toy model flows to an SYK-like model at low energy. A chaotic...

We study correlation functions in the one-dimensional \( \mathcal{N}=2 \) supersymmetric SYK model. The leading order 4-point correlation functions are computed by summing over ladder diagrams expanded in a suitable basis of conformal eigenfunctions. A novelty of the \( \mathcal{N}=2 \) model is that both symmetric and antisymmetric eigenfunctions are required. Although we use a...

We consider a supersymmetric SYK-like model without quenched disorder that is built by coupling two kinds of fermionic \( \mathcal{N}=1 \) tensor-valued superfields, “quarks” and “mesons”. We prove that the model has a well-defined large-N limit in which the (s)quark 2-point functions are dominated by mesonic “melon” diagrams. We sum these diagrams to obtain the Schwinger-Dyson...

The relation between the bosonic higher spin \( {\mathcal{W}}_{\infty}\left[\lambda \right] \) algebra, the affine Yangian of \( \mathfrak{g}{\mathfrak{l}}_1 \), and the SHc algebra is established in detail. For generic λ we find explicit expressions for the low-lying \( {\mathcal{W}}_{\infty}\left[\lambda \right] \) modes in terms of the affine Yangian generators, and deduce...

Twisted sectors arise naturally in the bosonic higher spin CFTs at their free points, as well as in the associated symmetric orbifolds. We identify the coset representations of the twisted sector states using the description of \( {\mathcal{W}}_{\infty } \) representations in terms of plane partitions. We confirm these proposals by a microscopic null-vector analysis, and by...

Background Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, a potential target for resolving depressive disorders. Our...

Background As a key strategy for mitigating global climate change, bioenergy production by reducing CO 2 emissions plays an important role in ensuring sustainable development. However, land-use change by converting natural ecosystems into energy crop field could create a carbon debt at the beginning. Thus, the potential carbon debt calculation is necessary for determining a...

As the amount of commercially available genetically modified organisms (GMOs) grows recent years, the diversity of target sequences for molecular detection techniques are eagerly needed. Considered as the gold standard for GMO analysis, the real-time PCR technology was optimized to produce a high-throughput GMO screening method. With this method we can detect 19 transgenic...

It has recently been argued that the symmetric orbifold theory of \( {\mathbb{T}}^4 \) is dual to string theory on AdS3 × S3 × \( {\mathbb{T}}^4 \) at the tensionless point. At this point in moduli space, the theory possesses a very large symmetry algebra that includes, in particular, a \( \mathcal{W} \) ∞ algebra capturing the gauge fields of a dual higher spin theory. Using...

For the proposed duality relating a family of \( \mathcal{N} \) = 4 superconformal coset models to a certain supersymmetric higher spin theory on AdS3, the asymptotic symmetry algebra of the bulk description is determined. It is shown that, depending on the choice of the boundary charges, one may obtain either the linear or the non-linear superconformal algebra on the boundary...

We determine the asymptotic symmetry algebra (for fields of low spin) of the M × M matrix extended Vasiliev theories on AdS3 and find that it agrees with the \( \mathcal{W} \)-algebra of their proposed coset duals. Previously it was noticed that for M = 2 the supersymmetry increases from \( \mathcal{N}=2 \) to \( \mathcal{N}=4 \). We study more systematically this type of...

Recent chromosome conformation capture (3C) derived techniques have revealed that topologically associating domain (TAD) is a pervasive element in chromatin three-dimensional (3D) organization. However, there is currently no parameter to quantitatively measure the structural characteristics of TADs, thus obscuring our understanding on the structural and functional differences...

Humans and other organisms are exposed to multi-chemical mixtures including commonly found carcinogens such as polycyclic aromatic hydrocarbons (PAHs) and heavy metal/loids. The joint effects of these chemicals as beyond the binary mixtures have not been well characterised. In this study, we evaluated the combined genotoxicity of mixtures of PAHs and heavy metal/loids containing...

Background The purpose of this study was to compare the shaping ability of the ProTaper Universal (PTU; Dentsply Maillefer, Ballaigues, Switzerland), WaveOne (WO; Dentsply Maillefer) and ProTaper Next (PTN; Dentsply Maillefer) in simulated L-shaped and S-shaped root canals respectively. Methods 30 simulated L-shaped and 30 simulated S-shaped root canals in resin blocks were...

We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Nature 2009, 459, 1146) of the AMPK homolog S. Pombe sucrose non-fermenting 1 (SNF1...

Most of herbal medicines of different sources are used for the same treatment goal in clinic despite their tremendous differences of the quality. Because the clinical efficacy is closely related to the quality of medicines, the implementation of an effective quality control (QC) process is vital. Chemical methods based on content determination and chromatographic fingerprints...

The 3D chromatin structure modeling by chromatin interactions derived from Hi-C experiments is significantly challenged by the intrinsic sequencing biases in these experiments. Conventional modeling methods only focus on the bias among different chromatin regions within the same experiment but neglect the bias arising from different experimental sequencing depth. We now show that...

Graphene and its derivative, graphene oxide (GO) have been substantively used as the main framework for dispersing or building nanoarchitectures because of their excellent properties in electronics and catalysis. The requirement to obtain superior graphene-metal hybrid nanomaterials has led us to explore a facile way to design 4-aminobenzenethiol/1-hexanethiolate-protected gold...

Colorectal cancer (CRC) displays a predilection for metastasis to liver. Although stromal cell-derived factor-1 (SDF-1)/CXCR4 plays an important role in the liver metastasis, the molecular mechanism still remains obscure. We previously reported that integrin αvβ6 was implicated in the progression of CRC. However, no data are currently available on the cross talk between CXCR4 and...