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9 papers found.
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Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies

Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance...

The nutraceutical benefits of subfractions of Abelmoschus esculentus in treating type 2 diabetes mellitus

: Chien-Ning Huang. Funding acquisition: Chiung-Huei Peng. Investigation: Chau-Jong Wang, Chih-Li Lin, Hui-Ting Lin, Chiung-Huei Peng. Resources: Chien-Ning Huang, Chau-Jong Wang, Chiung-Huei Peng

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

York (SUNY), Stony Brook, NY, 11794, USARuijuan Xu, Monica Garcia-Barros, Sally Wen, Fang Li, Chih-Li Lin, Yusuf A. Hannun, Lina M. Obeid & Cungui MaoCancer Center at State University of New York (SUNY ... ) at Stony Brook, Stony Brook, NY, 11794, USARuijuan Xu, Monica Garcia-Barros, Sally Wen, Fang Li, Chih-Li Lin, Yusuf A. Hannun, Lina M. Obeid & Cungui MaoDepartment of Gastroenterology, Nanfang Hospital

Depression in dementia with Lewy bodies: A comparison with Alzheimer's disease

Background Depression is highly associated with dementia, and this study will compare the frequencies, severity, and symptoms of depression between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Methods Frequency of depression was determined according to the DSM-IV criteria for major depression or the National Institute of Mental Health criteria for depression in...

Functional Roles of the Dimer-Interface Residues in Human Ornithine Decarboxylase

Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway. ODC is a dimeric enzyme, and the active sites of this enzyme reside at the dimer interface. Once the enzyme dissociates, the enzyme activity is lost. In this paper, we investigated the roles of amino acid residues at the...

Functional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation

Background Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation. However, mode of regulation that underlies the proper functional interaction of FACT and MCM is poorly understood. Methods & Results Here we present evidence indicating that such interaction is coordinated with cell cycle progression and...

Minimal Antizyme Peptide Fully Functioning in the Binding and Inhibition of Ornithine Decarboxylase and Antizyme Inhibitor

Antizyme (AZ) is a protein with 228 amino acid residues that regulates ornithine decarboxylase (ODC) by binding to ODC and dissociating its homodimer, thus inhibiting its enzyme activity. Antizyme inhibitor (AZI) is homologous to ODC, but has a higher affinity than ODC for AZ. In this study, we quantified the biomolecular interactions between AZ and ODC as well as AZ and AZI to...

WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway

The centromere is a highly specialized chromosomal element that is essential for chromosome segregation during mitosis. Centromere integrity must therefore be properly preserved and is strictly dependent upon the establishment and maintenance of surrounding chromatin structure. Here we identify WDHD1, a WD40-domain and HMG-domain containing protein, as a key regulator of...