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Search: authors:"Cho-Ming Chao"

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The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

’ Contributions Judith Gronbach, Tayyab Shahzad, and Harald Ehrhardt drafted the manuscript and designed the figures. Tobias Reicherzer provided valuable intellectual input. Sarah Radajewski, Cho-Ming Chao, Saverio

Generation and Validation of miR-142 Knock Out Mice

microRNA-142 (miR-142) is an important regulator of many biological processes and associated signaling pathways during embryonic development, homeostasis and disease. The miR-142 hairpin gives rise to the “guide strand” miR-142-3p and the sister "passenger" strand miR-142-5p. miR-142-3p has been shown to play critical, non-redundant functions in the development of the...

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally

The lung mesenchyme consists of a widely heterogeneous population of cells that play crucial roles during development and homeostasis after birth. These cells belong to myogenic, adipogenic, chondrogenic, neuronal and other lineages. Yet, no clear hierarchy for these lineages has been established. We have previously generated a novel Fgf10iCre knock-in mouse line that allows...

miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development

The regulation of the balance between proliferation and differentiation in the mesenchymal compartment of the lung is largely uncharacterized, unlike its epithelial counterpart. In this study, we determined that miR-142-3p contributes to the proper proliferation of mesenchymal progenitors by controlling the level of WNT signaling. miR-142-3p can physically bind to adenomatous...

Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion

Glucocorticoid excess predisposes to the development of diabetes, at least in part through impairment of insulin secretion. The underlying mechanism has remained elusive. We show here that dexamethasone upregulates transcription and expression of the serum- and glucocorticoid-inducible kinase 1 (SGK1) in insulin-secreting cells, an effect reversed by mifepristone (RU486), an...