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Much Ado about Cyber-space: Cyber-terrorism and the Reformation of the Cyber-security

The threats residing in cyber-space are becoming well understood by policymakers and security experts alike. However, cyber-security defenses and strategies cannot solely be directed towards nation states, as non-governmental actors – such as transnational crime groups and terrorist organizations are becoming increasingly reliant upon internet technologies. Attacks on the digital ...

‘All in a box’ a concept for optimizing microbiological diagnostic sampling in prosthetic joint infections

Background Accurate microbial diagnosis is crucial for effective management of prosthetic joint infections. Culturing of multiple intraoperative tissue samples has increased diagnostic accuracy, but new preparatory techniques and molecular methods hold promise of further improvement. The increased complexity of sampling is, however, a tough challenge for surgeons and assistants in ...

Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

The salicylidene acylhydrazide (SA) compounds have exhibited promising microbicidal properties. Previous reports have shown the SA compounds, using cell cultures, to exhibit activity against Chlamydia trachomatis, herpes simplex virus and HIV-1. In addition, using an animal model of a vaginal infection the SA compound INP0341, when dissolved in a liquid, was able to significantly ...

Surface Transition on Ice Induced by the Formation of a Grain Boundary

Interfaces between individual ice crystals, usually referred to as grain boundaries, play an important part in many processes in nature. Grain boundary properties are, for example, governing the sintering processes in snow and ice which transform a snowpack into a glacier. In the case of snow sintering, it has been assumed that there are no variations in surface roughness and ...

Synthetic Geopolymers for Controlled Delivery of Oxycodone: Adjustable and Nanostructured Porosity Enables Tunable and Sustained Drug Release

In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the preparation of different geopolymers, which could be structurally tailored by adjusting the Al/Si-ratio and the curing temperatures. In ...

Shoot, shovel and shut up: cryptic poaching slows restoration of a large carnivore in Europe

Olof Liberg Guillaume Chapron Petter Wabakken Hans Christian Pedersen N. Thompson Hobbs Hkan Sand 0 Norwegian Institute for Nature Research , Tungasletta 2, 7485 Trondheim , Norway 1 Department of

Performance metrics for Spanish investment funds

finance in the Faculty of Economics and Business Studies at the University of Zaragoza , Spain 1 Christian Pedersen is Director in Finance and Risk Management in Mercer, Oliver, Wyman. He holds a PhD on

Mammostrat® as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy

Introduction Patients with early-stage breast cancer, treated with endocrine therapy, have approximately 90% 5-year disease-free survival. However, for patients at higher risk of relapse despite endocrine therapy, additional adjuvant therapy, such as chemotherapy, may be indicated. The challenge is to prospectively identify such patients. The Mammostrat® test uses five ...

The Nature Index: A General Framework for Synthesizing Knowledge on the State of Biodiversity

The magnitude and urgency of the biodiversity crisis is widely recognized within scientific and political organizations. However, a lack of integrated measures for biodiversity has greatly constrained the national and international response to the biodiversity crisis. Thus, integrated biodiversity indexes will greatly facilitate information transfer from science toward other areas ...

Severe inbreeding depression in a wild wolf Canis lupus population

The difficulty of obtaining pedigrees for wild populations has hampered the possibility of demonstrating inbreeding depression in nature. In a small, naturally restored, wild population of grey wolves in Scandinavia, founded in 1983, we constructed a pedigree for 24 of the 28 breeding pairs established in the period 1983–2002. Ancestry for the breeding animals was determined ...