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Search: authors:"Christoph Boesecke"

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Exposure to previous cART is associated with significant liver fibrosis and cirrhosis in human immunodeficiency virus-infected patients

Trebicka. Data curation: Evrim Anadol, Kristina Lust, Christoph Boesecke, Carolynne Schwarze-Zan der, Raphael Mohr, Jan-Christian Wasmuth, JuÈrgen Kurt Rockstroh, Jonel Trebicka. Formal analysis: Evrim ... Anadol, Kristina Lust, Christoph Boesecke, Carolynne Schwarze-Zander, JuÈrgen Kurt Rockstroh, Jonel Trebicka. Funding acquisition: JuÈrgen Kurt Rockstroh, Jonel Trebicka. Investigation: JuÈrgen Kurt

Genetic polymorphisms associated with fatty liver disease and fibrosis in HIV positive patients receiving combined antiretroviral therapy (cART)

Hepatic steatosis can occur with any antiretroviral therapy (cART). Although single nucleotide polymorphisms (SNPs) have been identified to predispose to alcoholic and non-alcoholic fatty liver disease, their role for treatment-associated steatosis in HIV-positive patients remains unclear. We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), ...

Alterations of the NK cell pool in HIV/HCV co-infection

Background A relevant proportion of human immunodeficiency virus (HIV) infected patients is co-infected with the hepatitis C virus (HCV). HCV co-infection in HIV-positive patients is associated with faster progression of liver disease in comparison to HCV mono-infection. Natural killer (NK) cells critically modulate the natural course of HCV infection. Both HIV and HCV ...

Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy

Objectives To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996–1999 and survived for more than ten years. Methods We used data from 18 European and North American HIV cohort studies contributing to the Antiretroviral Therapy Cohort Collaboration. We followed up patients from ten years after start of ...

Survival and HLA-B*57 in HIV/HCV Co-Infected Patients on Highly Active Antiretroviral Therapy (HAART)

Background and aims HLA class I alleles, in particular HLA-B*57, constitute the most consistent host factor determining outcomes in untreated HCV- and HIV-infection. In this prospective cohort study, we analysed the impact of HLA class I alleles on all-cause mortality in patients with HIV-, HCV- and HIV/HCV- co-infection receiving HAART. Methods In 2003 HLA-A and B alleles were ...

Genetic Determinants of Idiopathic Noncirrhotic Portal Hypertension in HIV-Infected Patients

Background. Noncirrhotic portal hypertension (NCPH) is a rare but potentially life-threatening complication in patients with human immunodeficiency virus (HIV). Cases of NCPH have been reported in HIV-negative individuals as result of treatment with thiopurines for leukemia or inflammatory bowel disease. Exposure to didanosine, which is also a purine analogue, predisposes to NCPH ...

Liver Fibrosis Progression After Acute Hepatitis C Virus Infection in HIV-Positive Individuals

Fibrosis progression after acute hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)–infected patients with follow-up >9 months became similar to reported rates from studies in chronic HIV/HCV coinfection, as measured with transient elastometry. The duration of follow-up and serum alanine transaminase correlated with liver stiffness, and short follow-up resulted ...

Efavirenz versus Boosted Atazanavir or Zidovudine and Abacavir in Antiretroviral Treatment-Naive, HIV-Infected Subjects: Week 48 Data from the Altair Study

Puls, James Rooney, Sharon Walmsley, Alan Winston, Marcelo Wolff. Altair Study Team (Sydney and Buenos Aires). Sean Emery, Rebekah L Puls, Christoph Boesecke, Jaime Lazovski, Kathy Petoumenos, Marina

Activation and Coagulation Biomarkers Are Independent Predictors of the Development of Opportunistic Disease in Patients with HIV Infection

BackgroundActivation and coagulation biomarkers were measured within the Strategies for Management of Antiretroviral Therapy (SMART) trial. Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)–positive patients were examined MethodsInflammatory (high-sensitivity C-reactive protein [hsCRP], interleukin-6 [IL–6], amyloid-A, and amyloid-P) and ...