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Constraining new resonant physics with top spin polarisation information

We provide a comprehensive analysis of the power of including top quark-polarisation information to kinematically challenging top pair resonance searches, for which ATLAS and CMS start losing sensitivity. Following the general modelling and analysis strategies pursued by the experiments, we analyse the semi-leptonic and the di-lepton channels and show that including polarisation ...

Higgs coupling measurements at the LHC

Due to the absence of tantalising hints for new physics during the LHC’s Run 1, the extension of the Higgs sector by dimension-six operators will provide the new phenomenological standard for searches of non-resonant extensions of the Standard Model. Using all dominant and subdominant Higgs production mechanisms at the LHC, we compute the constraints on Higgs physics-relevant ...

Uninstructed BIAT faking when ego depleted or in normal state: differential effect on brain and behavior

Background Deception can distort psychological tests on socially sensitive topics. Understanding the cerebral processes that are involved in such faking can be useful in detection and prevention of deception. Previous research shows that faking a brief implicit association test (BIAT) evokes a characteristic ERP response. It is not yet known whether temporarily available ...

Off-shell Higgs coupling measurements in BSM scenarios

Proposals of measuring the off-shell Higgs contributions and first measurements at the LHC have electrified the Higgs phenomenology community for two reasons: firstly, probing interactions at high invariant masses and momentum transfers is intrinsically sensitive to new physics beyond the Standard Model, irrespective of a resonant or non-resonant character of a particular BSM ...

Constraining top quark effective theory in the LHC Run II era

We perform an up-to-date global fit of top quark effective theory to experimental data from the Tevatron, and from LHC Runs I and II. Experimental data includes total cross-sections up to 13 TeV, as well as differential distributions, for both single top and pair production. We also include the top quark width, charge asymmetries, and polarisation information from top decay ...

MiR-21 is required for efficient kidney regeneration in fish

Background Acute kidney injury in mammals, which is caused by cardiovascular diseases or the administration of antibiotics with nephrotoxic side-effects is a life-threatening disease, since loss of nephrons is irreversible in mammals. In contrast, fish are able to generate new nephrons even in adulthood and thus provide a good model to study renal tubular regeneration. Results ...

hhjj production at the LHC

The search for di-Higgs production at the LHC in order to set limits on the Higgs trilinear coupling and constraints on new physics is one of the main motivations for the LHC high-luminosity phase. Recent experimental analyses suggest that such analyses will only be successful if information from a range of channels is included. We therefore investigate di-Higgs production in ...

Higgs self-coupling measurements at a 100 TeV hadron collider

An important physics goal of a possible next-generation high-energy hadron collider will be precision characterisation of the Higgs sector and electroweak symmetry breaking. A crucial part of understanding the nature of electroweak symmetry breaking is measuring the Higgs self-interactions. We study dihiggs production in proton-proton collisions at 100 TeV centre of mass energy in ...

Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons

Thousands of tandem alternative splice sites (TASS) give rise to mRNA insertion/deletion variants with small size differences. Recent work has concentrated on the question of biological relevance in general, and the physiological regulation of TASS in particular. We have quantitatively studied 11 representative TASS cases in comparison to one mutually exclusive exon case and two ...

BOR-Syndrome-Associated Eya1 Mutations Lead to Enhanced Proteasomal Degradation of Eya1 Protein

Mutations in the human EYA1 gene have been associated with several human diseases including branchio-oto (BO) and branchio-oto-renal (BOR) syndrome, as well as congenital cataracts and ocular anterior segment anomalies. BOR patients suffer from severe malformations of the ears, branchial arches and kidneys. The phenotype of Eya1-heterozygous mice resembles the symptoms of human ...

Establishing jet scaling patterns with a photon

Staircase and Poisson scaling are two typical patterns we observe for the exclusive number of jets at high energy hadron colliders. We examine these scaling properties for photon plus jets production at the LHC and find that this channel is well suited to study these features. We illustrate and discuss when to expect each of the two patterns, how to induce a transition through ...

Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl

Susann Schu ler Judith Hauptmann Birgit Perner Michael M. Kessels Christoph Englert Britta Qualmann The sequence of MO sdpI_e3i3 was reported incorrectly in the Materials and Methods section. The

Gender Separation Increases Somatic Growth in Females but Does Not Affect Lifespan in Nothobranchius furzeri

According to life history theory, physiological and ecological traits and parameters influence an individual's life history and thus, ultimately, its lifespan. Mating and reproduction are costly activities, and in a variety of model organisms, a negative correlation of longevity and reproductive effort has been demonstrated. We are employing the annual killifish Nothobranchius ...

The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels

Background The African annual fish Nothobranchius furzeri has over recent years been established as a model species for ageing-related studies. This is mainly based on its exceptionally short lifespan and the presence of typical characteristics of vertebrate ageing. To substantiate its role as an alternative vertebrate ageing model, a transcript catalogue is needed, which can serve ...

TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels

The Wilms tumor gene WT1 encodes a zinc-finger transcription factor that is inactivated in a subset of pediatric kidney cancers. During embryogenesis, WT1 is expressed in a time- and tissue-specific manner in various organs including gonads and kidney but also in the hematopoietic system. Although widely regarded as a tumor suppressor gene, wild-type WT1 is overexpressed in a ...

Cofilin-1 Inactivation Leads to Proteinuria – Studies in Zebrafish, Mice and Humans

96 well plates and allowed to recover. For observation of rhodamine-labeled dextran passing the glomerular barrier, we used the Wt1b-GFP transgenic zebrafish line [19] which was a gift from Christoph ... Englert, Jena. Fluorescent FITCdextran clearance from the pupil of the embryo eye was measured in AB-wildtype embryos and evaluated as previously described in Hentschel et al. [18]. The animal protocol was

High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research

Background The annual fish Nothobranchius furzeri is the vertebrate with the shortest known life span in captivity. Fish of the GRZ strain live only three to four months under optimal laboratory conditions, show explosive growth, early sexual maturation and age-dependent physiological and behavioral decline, and express aging related biomarkers. Treatment with resveratrol and low ...