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Non-24: eine unterschätzte zirkadiane Schlafstörung bei Blinden

Die Nicht-24-Stunden-Schlaf-Wach-Störung, kurz Non-24, ist eine sehr seltene zirkadiane Rhythmusstörung. Sie kommt jedoch bei der Mehrzahl der völlig blinden Personen aufgrund der fehlenden Lichtempfindung als Zeitgeber für die Adjustierung ihres zirkadianen Schrittmachers, der inneren Uhr, vor. Bis zu 70 % der vollblinden Personen müssen damit leben, dass ihr intrinsischer ...

Narkolepsie nach Schweinegrippe – autoimmun, postinfektiös oder statistischer Fehler?

Lebensziele und wertebasiertes Handeln umfasst, die Lebensqualität bei Nonrespondern auf KVTI verbessern kann [2]. Dr. med. Lukas Frase, Dipl.-Psych. Elisabeth Hertenstein, Prof. Dr. med. Christoph Nissen Die ... Viren auftreten kann und welche Rolle die umstrittenen Wirkverstärker spielen, bleibt ungeklärt. Dr. med. Lukas Frase, Dipl.-Psych. Elisabeth Hertenstein, Prof. Dr. med. Christoph Nissen 1. Tesoriero C

Den Akku aufladen – Hirnstimulationsverfahren bei Fatigue

.-Psych. Elisabeth Hertenstein, Prof. Dr. med. Christoph Nissen 1. Chalah MA et al. Fatigue in Multiple Sclerosis: Neural correlates and the role of non-invasive brain stimulation. Frontiers in Cellular

Polysomnographic Characteristics of Sleep in Stroke: A Systematic Review and Meta-Analysis

Background Research on sleep after stroke has focused mainly on sleep disordered breathing. However, the extend to which sleep physiology is altered in stroke survivors, how these alterations compare to healthy volunteers, and how sleep changes might affect recovery as well as physical and mental health has yet to be fully researched. Motivated by the view that a deeper ...

Antidepressiva wirken auch bei Dysthymie

Psychiatry 0 Fragestellungen: Sind Antidepressiva bei Dysthymie wirksam? Wie ist die Wirksamkeit von Antidepressiva bei Dysthymie im Vergleich zu Major Depression? 0 0 Christoph Nissen , Freiburg i. Br

Krebskranke mit Depression sterben früher

Eine Depression ist bei Patienten mit Krebs häufig (13–40%). Vorangegangene Arbeiten wiesen darauf hin, dass eine Depression mit einer erhöhten Sterblichkeit assoziiert sein könnte. Das Ziel der vorliegenden Metaanalyse war eine Reevaluation des Zusammenhangs in einer großen Stichprobe und eine weitere Analyse des Einflusses verschiedener Moderatorvariablen wie der Schwere der ...

Fear Extinction as a Model for Synaptic Plasticity in Major Depressive Disorder

Background The neuroplasticity hypothesis of major depressive disorder proposes that a dysfunction of synaptic plasticity represents a basic pathomechanism of the disorder. Animal models of depression indicate enhanced plasticity in a ventral emotional network, comprising the amygdala. Here, we investigated fear extinction learning as a non-invasive probe for amygdala-dependent ...

Was ist im Alltag effektiver?

Oberarzt; Leitung der AG Neurophysiologie , Universitätsklinikum Freiburg 1 PD Dr. med. Christoph Nissen , Freiburg i. Br 1,2 1,0 0,2 0,0 0,54 0,49 0,09 GSI MCS PDT KVT 1 Effektstärken von PDT und KVT von

The prediction of treatment outcomes by early maladaptive schemas and schema modes in obsessive-compulsive disorder

Background Higher levels of early maladaptive schemas (EMS) and schema modes according to schematherapy by Jeffrey Young are present in obsessive-compulsive disorder (OCD) compared to healthy controls. This study examines the relationship of EMS and schema modes to OC symptom severity and the predictive value of EMS and schema modes on treatment outcome in inpatients receiving ...

The Relationship between Brain Morphology and Polysomnography in Healthy Good Sleepers

Background Normal sleep continuity and architecture show remarkable inter-individual variability. Previous studies suggest that brain morphology may explain inter-individual differences in sleep variables. Method Thirty-eight healthy subjects spent two consecutive nights at the sleep laboratory with polysomnographic monitoring. Furthermore, high-resolution T1-weighted MRI datasets ...

Quality of life changes following inpatient and outpatient treatment in obsessive-compulsive disorder: a study with 12 months follow-up

Background Quality of life (QoL) is increasingly recognized as a critical outcome parameter in mental health studies. The aim of this study was to investigate different domains of the QoL in persons with obsessive-compulsive disorder (OCD) before and after a multimodal, disorder-specific in- and outpatient treatment. Methods Data of 73 persons with OCD treated in an inpatient ...

The Timing of Learning before Night-Time Sleep Differentially Affects Declarative and Procedural Long-Term Memory Consolidation in Adolescents

Sleep after learning has been shown to foster the consolidation of new memories. However, fundamental questions on the best timing of learning before night-time sleep persist. We tested the hypothesis that learning directly prior to night-time sleep compared to 7.5 hrs prior to night-time sleep provides better conditions for the consolidation of declarative and procedural memories. ...

Mindfulness-based cognitive therapy in obsessive-compulsive disorder – A qualitative study on patients’ experiences

Background Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) is the first-line treatment for patients with obsessive-compulsive disorder (OCD). However, not all of them achieve remission on a longterm basis. Mindfulness-based cognitive therapy (MBCT) represents a new 8-week group therapy program whose effectiveness has been demonstrated in various ...