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Search: authors:"Christopher M. Read"

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Enthalpy–entropy compensation: the role of solvation

Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional explanation for such enthalpy–entropy compensation (EEC) is that tighter contacts lead ...

The DNA Bend Angle and Binding Affinity of an HMG Box Increased by the Presence of Short Terminal Arms

Mirna Lnenicek-Allen 0 Christopher M. Read 0 Colyn Crane-Robinson 0 0 Biophysics Laboratories, University of Portsmouth , St Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK The HMG box