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14 papers found.
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Visualizing tumor evolution with the fishplot package for R

Background Massively-parallel sequencing at depth is now enabling tumor heterogeneity and evolution to be characterized in unprecedented detail. Tracking these changes in clonal architecture often provides insight into therapeutic response and resistance. In complex cases involving multiple timepoints, standard visualizations, such as scatterplots, can be difficult to interpret. ...

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial

Background Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues. There are no reliable estimates of methemoglobinemia in low resource clinical settings. Our objectives were to: i) evaluate risk factors for methemoglobinemia in Ugandan children hospitalized with fever (study 1); and ii) investigate MHb ...

Partnering with health system operations leadership to develop a controlled implementation trial

Background Outcome for mental health conditions is suboptimal, and care is fragmented. Evidence from controlled trials indicates that collaborative chronic care models (CCMs) can improve outcomes in a broad array of mental health conditions. US Department of Veterans Affairs leadership launched a nationwide initiative to establish multidisciplinary teams in general mental health ...

A Cross-Sectional Study Comparing the Frequency of Drug Interactions After Adding Simeprevir- or Sofosbuvir-Containing Therapy to Medication Profiles of Hepatitis C Monoinfected Patients

version to be published. Conflict of interest. Mona Nasiri, Arden Koroglu, Steven Bliss, Melissa Davis, LouiseAnne McNutt, and Christopher Miller declare that they have no conflicts of interest. Dr. Patel

Intracellular Proton Access in a Cl−/H+ Antiporter

Mutagenesis, functional analysis, and crystal structures identify a watery tunnel through which protons enter the interior of a Cl−/H+ antiport protein involved in acid resistance of enteric bacteria.

A family of fluoride-specific ion channels with dual-topology architecture

Fluoride ion, ubiquitous in soil, water, and marine environments, is a chronic threat to microorganisms. Many prokaryotes, archea, unicellular eukaryotes, and plants use a recently discovered family of F− exporter proteins to lower cytoplasmic F− levels to counteract the anion’s toxicity. We show here that these ‘Fluc’ proteins, purified and reconstituted in liposomes and planar ...

A provisional transport mechanism for a chloride channel-type Cl−/H+ exchanger

Christopher Miller () 0 Wang Nguitragool 0 0 Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University , Waltham, MA 02454 , USA Chloride channel (CLC)-type ClK/HC exchangers

An overview of the potassium channel family

Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled ...

Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trial

Background Severe malaria remains a major cause of global morbidity and mortality. Despite the use of potent anti-parasitic agents, the mortality rate in severe malaria remains high. Adjunctive therapies that target the underlying pathophysiology of severe malaria may further reduce morbidity and mortality. Endothelial activation plays a central role in the pathogenesis of severe ...

The Use of Nonhuman Primate Models in HIV Vaccine Development

States of America. Christopher Miller is with the Department of Pathology, Microbiology and Immunology, California National Primate Research Center, School of Veterinary Medicine, University of California

Recombinant Bacille Calmette-Guérin Expressing the Measles Virus Nucleoprotein Protects Infant Rhesus Macaques from Measles Virus Pneumonia

Measles virus infection continues to be a major cause of infant mortality. There is a need for a measles vaccine that can be administered at birth in the presence of maternal neutralizing antibody. Infant rhesus monkeys were immunized with recombinant bacille Calmette-Guérin expressing the full-length measles virus nucleoprotein (BCG-N) and subsequently challenged with measles ...