Advanced search    

Search: authors:"Chun-Ming Wong"

10 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers

collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors declare that co-author Chun-Ming Wong is a PLOS ONE Editorial Board member and this does not

Requirement of CRTC1 coactivator for hepatitis B virus transcription

Transcription of hepatitis B virus (HBV) from the covalently closed circular DNA (cccDNA) template is essential for its replication. Suppressing the level and transcriptional activity of cccDNA might have anti-HBV effect. Although cellular transcription factors, such as CREB, which mediate HBV transcription, have been well described, transcriptional coactivators that facilitate...

Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is an aggressive tumor, with a high mortality rate due to late symptom presentation and frequent tumor recurrences and metastasis. It is also a rapidly growing tumor supported by different metabolic mechanisms; nevertheless, the biological and molecular mechanisms involved in the metabolic reprogramming in HCC are unclear. In this study, we found...

Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

-Pei Li Yingyos Avihingsanon Pornpimol Rianthavorn Thavatchai Deekajorndej Kanya Suphapeetiporn Vorasuk Shotelersuk Shirley King Yee Ying Samuel Ka Shun Fung Wai Ming Lai Chun-Ming Wong Irene Oi Lin Ng

Transcriptional Repressive H3K9 and H3K27 Methylations Contribute to DNMT1-Mediated DNA Methylation Recovery

DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis. DNA methylation plays an important role in tumor suppressor gene inactivation, and can be revised by DNA methylation inhibitors. The reversible nature of DNA methylation forms the basis of...

Genome-Wide Association Study of Hepatocellular Carcinoma in Southern Chinese Patients with Chronic Hepatitis B Virus Infection

One of the most relevant risk factors for hepatocellular carcinoma (HCC) development is chronic hepatitis B virus (HBV) infection, but only a fraction of chronic HBV carriers develop HCC, indicating that complex interactions among viral, environmental and genetic factors lead to HCC in HBV-infected patients. So far, host genetic factors have incompletely been characterized...

Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus

Suphapeetiporn 5 Vorasuk Shotelersuk 5 Shirley King Yee Ying 3 Samuel Ka Shun Fung 3 Wai Ming Lai 0 Chun- Ming Wong 7 Irene Oi Lin Ng 7 Maria-Merce Garcia-Barcelo 12 Stacey S. Cherny 11 Paul Kwong-Hang Pak Chung

Deleted in Liver Cancer 1 (DLC1) Negatively Regulates Rho/ROCK/MLC Pathway in Hepatocellular Carcinoma

Aims Deleted in liver cancer 1 (DLC1), a member of RhoGTPase activating protein (GAP) family, is known to have suppressive activities in tumorigenicity and cancer metastasis. However, the underlying molecular mechanisms of how DLC1 suppresses cell motility have not been fully elucidated. Rho-kinase (ROCK) is an immediate down-stream effector of RhoA in mediating cellular...

ELF1 is associated with systemic lupus erythematosus in Asian populations

Hok Kung Ho 7 Pamela Pui Wah Lee 7 Wilfred Hing Sang Wong 7 Shuai Zeng 7 Jing Zhang 7 Chun-Ming Wong 5 Irene Oi Lin Ng 5 Maria-Merce` Garcia-Barcelo 10 Stacey S. Cherny 9 Paul Kwong-Hang Tam 10 Pak

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

Chun-Ming Wong Tsz Leung Lee Marco Hok Kung Ho Pamela Pui Wah Lee Yuk Kwan Chang Philip H. Li Ruo-Jie Li Lu Zhang Wilfred Hing Sang Wong Irene Oi Lin Ng Chak Sing Lau Pak Chung Sham Yu Lung Lau Asian