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Deciphering the trophic interaction between <Emphasis Type=

Host glycans are paramount in regulating the symbiotic relationship between humans and their gut bacteria. The constant flux of host-secreted mucin at the mucosal layer creates a steady niche for bacterial colonization. Mucin degradation by keystone species subsequently shapes the microbial community. This study investigated the transcriptional response during mucin-driven...

Association between duration of intravenous antibiotic administration and early-life microbiota development in late-preterm infants

Netherlands 2 Clara Belzer 3 Princess Amalia Children's Centre, Department of Paediatrics and Neonatology, Isala , Zwolle , The Netherlands Antibiotic treatment is common practice in the neonatal ward for the ... from Jan Knol and Clara Belzer contributed equally. birth to childhood and adulthood is a process that co-occurs with maturation of the immune, digestive and cognitive systems. The interplay between

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

Sovran, Katrine Graversen, Myrte Huijskes, Eva Houtsma. Methodology: Marlies Elderman, Bruno Sovran, Floor Hugenholtz, Clara Belzer, Mark Boekschoten, Paul de Vos, Jan Dekker, Jerry Wells, Marijke Faas ... , Jan Dekker, Jerry Wells, Marijke Faas. Visualization: Marlies Elderman, Bruno Sovran, Floor Hugenholtz, Clara Belzer, Mark Boekschoten. Writing ± original draft: Marlies Elderman, Bruno Sovran. 19

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study

. Methodology: Pieter F. de Groot, Willem M. de Vos, Max Nieuwdorp. Project administration: Pieter F. de Groot, Max Nieuwdorp. Supervision: Pieter F. de Groot, Clara Belzer, Willem M. de Vos, Max Nieuwdorp ... . Validation: Pieter F. de Groot. Visualization: Pieter F. de Groot, Evgeni Levin. Writing ± original draft: Pieter F. de Groot. Writing ± review & editing: Clara Belzer, Frits Holleman, DanieÈl H. van Raalte

Intestinal Ralstonia pickettii augments glucose intolerance in obesity

. de Vos, Max Nieuwdorp. Data curation: Shanthadevi D. Udayappan, Kristien E. Bouter, Clara Belzer, Noor de Sonnaville, Daniel H. van Raalte, GoÈran BergstroÈm. Formal analysis: Petia Kovatcheva

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study

Purpose The intestinal microbiota has emerged as a virtual organ with essential functions in human physiology. Antibiotic-induced disruption of the microbiota in critically ill patients may have a negative influence on key energy resources and immunity. We set out to characterize the fecal microbiota composition in critically ill patients both with and without sepsis and to...

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. This highly complex system involves numerous microbiota-derived factors. The gut symbiont Akkermansia muciniphila is positively correlated with a lean phenotype, reduced body weight...

Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance of Pseudomonas aeruginosa Lung Infection in Mice by Modulating Intestinal Microbiota and Immunity

Background. A predominantly T-helper type 2 (Th2) immune response is critical in the prognosis of pulmonary Pseudomonas aeruginosa infection. But the mucosal and systemic immune responses can be influenced by the intestinal microbiota. Methods. We assessed the effect of microbiota compositional changes induced by a diet enriched in 5% acidic oligosaccharides derived from pectin...

Dynamics of the Microbiota in Response to Host Infection

Longitudinal studies of the microbiota are important for discovering changes in microbial communities that affect the host. The complexity of these ecosystems requires rigorous integrated experimental and computational methods to identify temporal signatures that promote physiologic or pathophysiologic responses in vivo. Employing a murine model of infectious colitis with the...

Metal-responsive gene regulation and metal transport in Helicobacter species

Clara Belzer 0 Jeroen Stoof 0 Arnoud H. M. van Vliet 0 0 C. Belzer J. Stoof A. H. M. van Vliet (&) Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center , Room L-455