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22 papers found.
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Micronutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer Subtypes

Background Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes. Methods...

Dietary Total Antioxidant Capacity and Colorectal Cancer in the Italian EPIC Cohort

Background Colorectal cancer is the third most common cancer worldwide. Diet has been hypothesized as involved in colorectal cancer etiology, but few studies on the influence of total dietary antioxidant intake on colorectal cancer risk have been performed. Methods We investigated the association between colorectal cancer risk and the total antioxidant capacity (TAC) of the diet...

Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohort

The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant transformation and improve diagnosis and prognosis. In the...

Metabolic Syndrome and Breast Cancer Risk: A Case-Cohort Study Nested in a Multicentre Italian Cohort

Background Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, low high-density lipoprotein cholesterol, high blood glucose, and high blood pressure) is emerging as a risk factor for breast cancer; however few studies – most confined to postmenopausal women – have investigated associations between breast cancer risk and metabolic...

Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort

Background The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. Methods We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR...

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Background Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is associated with increased risk of breast cancer. We report on three independent prospective nested case-control studies from...

Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

Background DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA...

Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes

Emily Sonestedt Giovanna Masala Claudia Agnoli Rosario Tumino Annemieke MW Spijkerman Aurelio Barricarte Fulvio Ricceri Saioa Chamosa Ingegerd Johansson Anna Winkvist Anne Tjnneland Diewertje Sluik Heiner

Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort

Eva S Schernhammer 0 1 2 4 Francesca Sperati 8 Pedram Razavi 7 Claudia Agnoli 6 Sabina Sieri 6 Franco Berrino 5 Vittorio Krogh 6 Carlo Alberto Abbagnato 10 Sara Grioni 6 Giovanni Blandino 8 9 Holger

Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study

Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European...

Dietary Glycemic Load and Glycemic Index and Risk of Cerebrovascular Disease in the EPICOR Cohort

Background Studies on the association of stroke risk to dietary glycemic index (GI) and glycemic load (GL) have produced contrasting results. Objective To investigate the relation of dietary GI and GL to stroke risk in the large EPIC-Italy cohort (EPICOR) recruited from widely dispersed geographic areas of Italy. Design We studied 44099 participants (13,646 men and 30,453 women...

Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Olsen Franoise Clavel-Chapelon Guy Fagherazzi Florence Perquier Birgit Teucher Rudolf Kaaks Madlen Schtze Heiner Boeing Pagona Lagiou Philippos Orfanos Antonia Trichopoulou Claudia Agnoli Amalia Mattiello

Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Fish is a source of important nutrients and may play a role in preventing heart diseases and other health outcomes. However, studies of overall mortality and cause-specific mortality related to fish consumption are inconclusive. We examined the rate of overall mortality, as well as mortality from ischaemic heart disease and cancer in relation to the intake of total fish, lean...

Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

Heiner Boeing Antonia Trichopoulou Pagona Lagiou Dimitrios Trichopoulos Domenico Palli Claudia Agnoli Rosario Tumino Paolo Vineis Salvatore Panico H. Bas Bueno-de-Mesquita Petra H Peeters Elisabete

Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study

Froguel Leif C. Groop Torben Hansen Luigi Palla Oluf Pedersen Matthias B. Schulze Maria-Jose Tormo Eleanor Wheeler Claudia Agnoli Larraitz Arriola Aurelio Barricarte Heiner Boeing Geraldine M. Clarke Fran

Dietary Fat Intake and Development of Specific Breast Cancer Subtypes

IRCCS Istituto Nazionale dei Tumori , Via Venezian 1, I-20133 Milan , Italy ( 2 Sabina Sieri , Paolo Chiodini, Claudia Agnoli, Valeria Pala, Franco Berrino, Antonia Trichopoulou, Vassiliki Benetou, Effie

Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort—A Factor Analysis

Birgit Teucher Jenny Chang-Claude Heiner Boeing Dagmar Drogan Antonia Trichopoulou Vasiliki Benetou Christina Bamia Domenico Palli Claudia Agnoli Rocco Galasso Rosario Tumino Carlotta Sacerdote H. Bas ... . ACKNOWLEDGMENTS Mixte de Recherche Scientifique 1018, Paris South Univer e Cura a Carattere Scientifico), Istituto Nazionale Tumori, Milan, Italy (Claudia Agnoli); Istituto di Ricovero e Cura a Carattere

Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study

Trichopoulou Domenico Palli Claudia Agnoli Rosario Tumino Paolo Vineis Salvatore Panico H. Bas Bueno-de-Mesquita Monique Verschuren Isabel Drake Emily Sonestedt Tonje Braaten Sabina Rinaldi Isabelle Romieu Nadia

Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC)

The single-nucleotide polymorphisms (SNPs) rs402710 (5p15.33), rs16969968 and rs8034191 (15q25.1) have been consistently identified by genome-wide association studies (GWAS) as significant predictors of lung cancer risk, while rs4324798 (6p22.1) was previously found to influence survival time in small-cell lung cancer (SCLC) patients. Using the same population of one of the...

Sources of Pre-Analytical Variations in Yield of DNA Extracted from Blood Samples: Analysis of 50,000 DNA Samples in EPIC

-Chapelon Antonia Trichopoulou Dimitrios Trichopoulos Pagona Lagiou Heiner Boeing Eva Fisher Rosario Tumino Claudia Agnoli Pierre Hainaut Gualtiero Colombo, Centro Cardiologico Monzino IRCCS, Italy The