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Renin-angiotensin system inhibitors in kidney transplantation: a benefit-risk assessment

, 20089 Rozzano, MI , Italy 1 Claudio Ponticelli Vol.:(011233456789) - Arterial hypertension is frequent in kidney transplant recipients and may lead to severe complications, including cardiac failure

Ischaemia-reperfusion injury: a major protagonist in kidney transplantation

Ischaemia-reperfusion injury (IRI) is a frequent event in kidney transplantation, particularly when the kidney comes from a deceased donor. The brain death is usually associated with generalized ischaemia due to a hyperactivity of the sympathetic system. In spite of this, most donors have profound hypotension and require administration of vasoconstrictor agents. Warm ischaemia...

Tonsillectomy and IgA nephritis

IgA nephritis (IgAN) is an autoimmune disease characterized by deposits of IgA in the glomerular mesangium. Clinically, the disease may be punctuated by episodes of macroscopic haematuria often associated with pharingotonsillitis or may be oligosyntomatic with microscopic haematuria and mild proteinuria. The natural course of IgAN may be indolent and benign; however, some 30–50...

The dialysis scenario in patients with systemic lupus erythematosus

Although prognosis of lupus nephritis has improved over time, a substantial amount of lupus patients still reach end-stage renal disease and require dialysis. Treatment of these patients can be challenging, since the disease poses a number of problems that can portend a poor prognosis, such as infections, lupus reactivations, vascular access thrombosis and cardiovascular...

Herpes viruses and tumours in kidney transplant recipients. The role of immunosuppression

Herpes virus infections are frequent in renal transplant recipients. Some herpes viruses are not only responsible for life-threatening infections and renal graft injury but can also increase the risk of malignancy. Three herpes viruses, namely cytomegalovirus (CMV) or human herpes virus 5, Epstein–Barr virus (EBV) or herpes virus 4 and human herpes virus 8 (HHV8), may play an...

Glomerular diseases and cancer: evaluation of underlying malignancy

Onconephrology is an emerging medical subspecialty focused on the numerous interconnections between cancer and kidney diseases. Patient with malignancies commonly experience kidney problems including acute kidney injury, tumor lysis syndrome, fluid and electrolyte disorders and chronic kidney disease, often as a consequence of the anti-cancer treatment. Conversely, a number of...

Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantation

Claudio Ponticelli 0 0 Division of Nephrology, Istituto Scientifico Humanitas , via Manzoni 56, 20089 Rozzano, Milano, Italy Focal segmental glomerular sclerosis (FSGS) is a pathological term to ... clearly exposed to and discussed with the donor and the recipient and preemptive plasma exchange should be planned. Conflict of interest statement. Claudio Ponticelli is consultant of Novartis Italy and

New recommendations in the treatment of Gram-positive bacteraemia in dialysis patients

Istituto Auxologico Italiano Milan Italy Correspondence and offprint requests to: Dr Claudio Ponticelli, Istituto Auxologico Italiano, Via Ampere 126, 20131 Milano, Italy. Tel: +39-0226112952; Fax

Glomerular diseases and transplantation: similarities in pathogenetic mechanisms and treatment options

Glomerular diseases and renal transplantation have always been considered as independent fields of nephrology, due to the supposed prevalent role of antibody production and immune complex formation in glomerulonephritis versus a direct reaction of immune cell towards the grafted kidney. However, both conditions share common pathogenetical pathways, and possible new therapeutic...

Renal transplantation 2004: where do we stand today?

Claudio Ponticelli Ospedale San Luca Istituto Scientific Auxologica In spite of considerable progress in immunosuppressive and supportive treatment, numerous problems persist which interfere with

Haemophagocytic syndrome—a life-threatening complication of renal transplantation

Claudio Ponticelli 1 Ornella Della Casa Alberighi 0 0 IRCCS G. Gaslini, Clinical Pharmacology , Genova, Italy 1 Division of Nephrology, IRCCS Istituto Clinico Humanitas , Rozzano, Milano C The

Renal function in patients with β-thalassaemia major: a long-term follow-up study†

Background Little information is available about the kidney's involvement in patients with β-thalassaemia major (TM). In particular, there are no studies reporting the outcome of renal function over time.

Renal allograft thrombosis

-directed thrombolysis may also allow the return of kidney function in some patients [70]. Conflict of interest statement. Claudio Ponticelli is a Consultant of Novartis Pharma, Italy.

Acute kidney injury due to deferoxamine in a renal transplant patient

Nephrol Dial Transplant Raimund Hirschberg William Bennett Jon Scheinman 0 Rosanna Coppo Claudio Ponticelli 0 Hannover Medical School Jessica Wortmann 4. Auckley DH, Schmidt-Nowara W, Brown LK

Role of anaemia in cardiovascular mortality and morbidity in transplant patients

Claudio Ponticelli 0 Margarita Villa 0 0 Department of Nephro-Urology and Kidney Transplantation, IRCCS Ospedale Maggiore di Milano , Via Commenda 15, 20122 Milan , Italy Cardiovascular