GPR40 (FFA1) is a fatty acid receptor whose activation results in potent glucose lowering and insulinotropic effects in vivo. Several reports illustrate that GPR40 agonists exert glucose lowering in diabetic humans. To assess the mechanisms by which GPR40 partial agonists improve glucose homeostasis, we evaluated the effects of MK-2305, a potent and selective partial GPR40...
, Daphne Szeto, Corin Miller, Michelle Bunzel, Sarah Souza, Brande S. Thomas-Fowlkes, Aimie M. Ogawa, Adam B. Weinglass, Yue Feng, Maria E. Trujillo. Methodology: Michele J. Pachanski, Boonlert ... Cheewatrakoolpong, Jiyan Xue, Daphne Szeto, Gail Forrest, Corin Miller, Michelle Bunzel, Sarah Souza, Brande S. Thomas-Fowlkes, Aimie M. Ogawa, Adam B. Weinglass, Xiaoyan Li, Yue Feng, Daniel A. Tatosian, Maria E
Glucagon maintains glucose homeostasis during the fasting state by promoting hepatic gluconeogenesis and glycogenolysis. Hyperglucagonemia and/or an elevated glucagon-to-insulin ratio have been reported in diabetic patients and animals. Antagonizing the glucagon receptor is expected to result in reduced hepatic glucose overproduction, leading to overall glycemic control. Here we...