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Search: authors:"Cristina Di Poto"

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Identification of race-associated metabolite biomarkers for hepatocellular carcinoma in patients with liver cirrhosis and hepatitis C virus infection

Institute of the National Institutes of Health under Award Numbers U01CA185188 and R01CA143420. Author Contributions Conceptualization: Habtom W. Ressom. Data curation: Cristina Di Poto, Shisi He, Rency S ... . Varghese, Yi Zhao, Alessia Ferrarini. Formal analysis: Cristina Di Poto, Shisi He, Yi Zhao, Mahlet G. Tadesse. Methodology: Cristina Di Poto, Alessia Ferrarini. Project administration: Cristina Di Poto

GC-MS Based Plasma Metabolomics for Identification of Candidate Biomarkers for Hepatocellular Carcinoma in Egyptian Cohort

This study evaluates changes in metabolite levels in hepatocellular carcinoma (HCC) cases vs. patients with liver cirrhosis by analysis of human blood plasma using gas chromatography coupled with mass spectrometry (GC-MS). Untargeted metabolomic analysis of plasma samples from participants recruited in Egypt was performed using two GC-MS platforms: a GC coupled to single...

Multi-profile Bayesian alignment model for LC-MS data analysis with integration of internal standards

Motivation: Liquid chromatography-mass spectrometry (LC-MS) has been widely used for profiling expression levels of biomolecules in various ‘-omic’ studies including proteomics, metabolomics and glycomics. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time (RT) alignment, which is required to ensure that ion...