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The effect of mechanical pre-processing and different drying methodologies on bioethanol production using the brown macroalga Laminaria digitata (Hudson) JV Lamouroux

pressings <10% of water and particulates were separated from 5 kg samples of material processed with or without a press aid (D. Thomas, personal communication). However, the screw press did operate as

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

Mills 0 Diane Kang 0 Paul D. Thomas 0 0 Division of Bioinformatics, Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California , Los Angeles, CA 90033 , USA *To

Genomes OnLine Database (GOLD) v.6: data updates and feature enhancements

The Genomes Online Database (GOLD) (https://gold.jgi.doe.gov) is a manually curated data management system that catalogs sequencing projects with associated metadata from around the world. In the current version of GOLD (v.6), all projects are organized based on a four level classification system in the form of a Study, Organism (for isolates) or Biosample (for environmental ...

Affordable, modular, and breathable upper-limb prosthetic sockets for use in underdeveloped areas with hot, humid climates

Amputees in underdeveloped areas often do not receive suitable prosthetic devices within the time frame needed for probable success. Typically, prostheses are either not secure or too constrictive of the residual limb. As a result, the constant friction and moisture collectionincrease the likelihood of skin breakdown. Furthermore, patients living in hot, humid climates are more ...

Structures of replication initiation proteins from staphylococcal antibiotic resistance plasmids reveal protein asymmetry and flexibility are necessary for replication

Antibiotic resistance in pathogenic bacteria is a continual threat to human health, often residing in extrachromosomal plasmid DNA. Plasmids of the pT181 family are widespread and confer various antibiotic resistances to Staphylococcus aureus. They replicate via a rolling circle mechanism that requires a multi-functional, plasmid-encoded replication protein to initiate replication, ...

Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037

Purpose Tumours frequently have defects in multiple oncogenic pathways, e.g. MAPK and PI3K signalling pathways, and combinations of targeted therapies may be required for optimal activity. This study evaluated the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037, as single agents and in combination, in colorectal carcinoma cell lines and tumour xenograft-bearing mice. ...

PANTHER version 10: expanded protein families and functions, and analysis tools

PANTHER (Protein Analysis THrough Evolutionary Relationships, http://pantherdb.org) is a widely used online resource for comprehensive protein evolutionary and functional classification, and includes tools for large-scale biological data analysis. Recent development has been focused in three main areas: genome coverage, functional information (‘annotation’) coverage and accuracy, ...

Large-scale inference of gene function through phylogenetic annotation of Gene Ontology terms: case study of the apoptosis and autophagy cellular processes

We previously reported a paradigm for large-scale phylogenomic analysis of gene families that takes advantage of the large corpus of experimentally supported Gene Ontology (GO) annotations. This ‘GO Phylogenetic Annotation’ approach integrates GO annotations from evolutionarily related genes across ∼100 different organisms in the context of a gene family tree, in which curators ...

Impact of grazing intensity on seasonal variations in soil organic carbon and soil CO2 efflux in two semiarid grasslands in southern Botswana

Andrew D. Thomas 0 0 Institute of Geography & Earth Sciences, Aberystwyth University , Llandinam Building, Aberystwyth, SY23 3DB Biological soil crusts (BSCs) are an important source of organic

Rotational thromboelastometry and multiple electrode platelet aggregometry in four patients with abnormal routine coagulation studies before removal of epidural catheters after major surgery: a case series and research study

Introduction Routine coagulation tests have a low predictability for perioperative bleeding complications, and spinal hematoma after removal of epidural catheters is very infrequent. Thromboelastometry and point-of-care platelet aggregometry may improve hemostatic monitoring but have not been studied in the context of safety around epidural removal. Methods Twenty patients who ...

Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid

The archetypal Th2 cytokine IL-4 has previously been shown to alternatively activate murine macrophages and, more recently, dendritic cells (DCs) both in vitro and in vivo. IL-4 has also been shown to induce Aldh1a2 (aldehyde dehydrogenase 1a2) expression in murine macrophages recruited to the peritoneal cavity. However, the influence of IL-4 on DC Aldh1a2 induction in vivo has not ...

Two Species with an Unusual Combination of Traits Dominate Responses of British Grasshoppers and Crickets to Environmental Change

There are large variations in the responses of species to the environmental changes of recent decades, heightening interest in whether their traits may explain inter-specific differences in range expansions and contractions. Using a long-term distributional dataset, we calculated range changes of grasshoppers and crickets in Britain between the 1980s and the 2000s and assessed ...

InterPro in 2017—beyond protein family and domain annotations

Lorna Richardson 8 Catherine Rivoire 12 Amaia Sangrador-Vegas 8 Christian Sigrist 12 Ian Sillitoe 0 Ben Smithers 10 Silvano Squizzato 8 Granger Sutton 15 Narmada Thanki 5 Paul D Thomas 9 Silvio C. E

Tumor Necrosis Factor (TNF) Receptor Superfamily Member 1b on CD8+ T Cells and TNF Receptor Superfamily Member 1a on Non-CD8+ T Cells Contribute Significantly to Upper Genital Tract Pathology Following Chlamydial Infection

Background. We demonstrated previously that tumor necrosis factor α (TNF-α)–producing Chlamydia-specific CD8+ T cells cause oviduct pathological sequelae. Methods. In the current study, we used wild-type C57BL/6J (WT) mice with a deficiency in genes encoding TNF receptor superfamily member 1a (TNFR1; TNFR1 knockout [KO] mice), TNF receptor superfamily member 1b (TNFR2; TNFR2 KO ...

Evolutionary Diagnosis of non-synonymous variants involved in differential drug response

Background Many pharmaceutical drugs are known to be ineffective or have negative side effects in a substantial proportion of patients. Genomic advances are revealing that some non-synonymous single nucleotide variants (nsSNVs) may cause differences in drug efficacy and side effects. Therefore, it is desirable to evaluate nsSNVs of interest in their ability to modulate the drug ...