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Optimal biological dose: a systematic review in cancer phase I clinical trials

Montpellier, 208 rue des Apothicaire, 34298, Montpellier Cedex 5, France J. Fraisse, D. Tosi & C. Mollevi Inserm CIC1401, Module Epidémiologie clinique, Institut Bergonié, Bordeaux, France D. Dinart & C ... for this author in PubMed Google Scholar D. Dinart View author publications You can also search for this author in PubMed Google Scholar D. Tosi View author publications You can also search

An Empirical Study on the Factors Affecting Software Development Productivity

function [5] L. Lavazza , S. Morasca , and D. Tosi , “ An empiri- points,” IEEE Software, Vol. 14 , No. 2, Mar. cal study on the effect of programming languages 1997 , pp. 29 - 31 . on productivity,” in

GUIP1: a R package for dose escalation strategies in phase I cancer clinical trials

. Dinart & C. Bellera Institut du Cancer Montpellier (ICM), Université de Montpellier, Montpellier, France J. Fraisse, D. Tosi, C. Touraine, S. Gourgou & C. Mollevi Memorial Sloan Kettering Cancer Center ...  Google Scholar J. Fraisse View author publications You can also search for this author in PubMed Google Scholar D. Tosi View author publications You can also search for this author in PubMed

Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue.

Spinal cord injury (SCI) is a devastating disease, which leads to paralysis and is associated to substantially high costs for the individual and society. At present, no effective therapies are available. Here, the use of mechanically-activated lipoaspirate ...

Multi-fiber distributed thermal profiling of minimally invasive thermal ablation with scattering-level multiplexing in MgO-doped fibers.

We propose a setup for multiplexed distributed optical fiber sensors capable of resolving temperature distribution in thermo-therapies, with a spatial resolution of 2.5 mm over multiple fibers interrogated simultaneously. The setup is based on optical ...

Magnetically-coupled piston pump for high-purity gas applications

Experiments based on noble elements such as gaseous or liquid argon or xenon utilize the ionization and scintillation properties of the target materials to detect radiation-induced recoils. A requirement for high light and charge yields is to reduce electronegative impurities well below the ppb (parts per billion, 1 ppb \(=1\times 10^{-9}\) mol/mol) level. To achieve this, the...

Multidimensional thermal mapping during radiofrequency ablation treatments with minimally invasive fiber optic sensors.

from our study. Acknowledgments Nazarbayev University (grant LIFESTART); University of Naples “Parthenope”. Funding D. Tosi ackowledges the support of ORAU program at Nazarbayev University (grant

Acetylcholine Protects against Candida albicans Infection by Inhibiting Biofilm Formation and Promoting Hemocyte Function in a Galleria mellonella Infection Model.

Both neuronal acetylcholine and nonneuronal acetylcholine have been demonstrated to modulate inflammatory responses. Studies investigating the role of acetylcholine in the pathogenesis of bacterial infections have revealed contradictory findings with ...

A histological procedure to study fungal infection in the wax moth Galleria mellonella.

Infection in the Wax Moth Galleria Mellonella F. Perdoni,1 M. Falleni,1,2 D. Tosi,1,2 D. Cirasola,1,3 S. Romagnoli,2 P. Braidotti,2 E. Clementi,4 G. Bulfamante,1,2 and E. Borghi1 F. Perdoni 1Department of ... D. Tosi 1Department of Health Sciences, University of Milan 2Pathology Unit, San Paolo Hospital, Milan Find articles by D. Tosi D. Cirasola 1Department of Health Sciences, University of Milan

FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer

Tosi, D Desigaud, E Perez-Gracia, C Larbouret, M Jarlier, V Denis, L K Linares, P Martineau, M Del Rio & C GongoraINSERM, U1194, Montpellier F-34298, FranceL Marzi, E Combes, N Vié, A Ayrolles-Torro, D ... -Torro, D Tosi, D Desigaud, E Perez-Gracia, C Larbouret, M Jarlier, V Denis, L K Linares, P Martineau, M Del Rio & C GongoraInstitut régional du Cancer Montpellier, Montpellier F-34298, FranceL Marzi, E

Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel

Background: The additive cytotoxicity in vitro prompted a clinical study evaluating the non-prodrug rapamycin analogue ridaforolimus (AP23573; MK-8669; formerly deforolimus) administered i.v. combined with paclitaxel (PTX; Taxol). Materials and methods: Patients with taxane-sensitive solid tumors were eligible. The main dose escalation foresaw 50% ridaforolimus increments from 25...

Development of an analysis to probe the neutrino mass ordering with atmospheric neutrinos using three years of IceCube DeepCore data

The Neutrino Mass Ordering (NMO) remains one of the outstanding questions in the field of neutrino physics. One strategy to measure the NMO is to observe matter effects in the oscillation pattern of atmospheric neutrinos above \(\sim 1\,\mathrm {GeV}\), as proposed for several next-generation neutrino experiments. Moreover, the existing IceCube DeepCore detector can already...

Search for steady point-like sources in the astrophysical muon neutrino flux with 8 years of IceCube data

The IceCube Collaboration has observed a high-energy astrophysical neutrino flux and recently found evidence for neutrino emission from the blazar TXS 0506\(+\)056. These results open a new window into the high-energy universe. However, the source or sources of most of the observed flux of astrophysical neutrinos remains uncertain. Here, a search for steady point-like neutrino...

Search for neutrinos from decaying dark matter with IceCube

With the observation of high-energy astrophysical neutrinos by the IceCube Neutrino Observatory, interest has risen in models of PeV-mass decaying dark matter particles to explain the observed flux. We present two dedicated experimental analyses to test this hypothesis. One analysis uses 6 years of IceCube data focusing on muon neutrino ‘track’ events from the Northern Hemisphere...

Measurement of the \(\nu _{\mu }\) energy spectrum with IceCube-79

IceCube is a neutrino observatory deployed in the glacial ice at the geographic South Pole. The \(\nu _\mu \) energy unfolding described in this paper is based on data taken with IceCube in its 79-string configuration. A sample of muon neutrino charged-current interactions with a purity of 99.5% was selected by means of a multivariate classification process based on machine...

Search for neutrinos from dark matter self-annihilations in the center of the Milky Way with 3 years of IceCube/DeepCore

. Stezelberger R. G. Stokstad A. Stößl N. L. Strotjohann G. W. Sullivan M. Sutherland I. Taboada J. Tatar F. Tenholt S. Ter-Antonyan A. Terliuk G. Tešic´ S. Tilav P. A. Toale M. N. Tobin S. Toscano D. Tosi M

Search for annihilating dark matter in the Sun with 3 years of IceCube data

We present results from an analysis looking for dark matter annihilation in the Sun with the IceCube neutrino telescope. Gravitationally trapped dark matter in the Sun’s core can annihilate into Standard Model particles making the Sun a source of  GeV neutrinos. IceCube is able to detect neutrinos with energies >100 GeV while its low-energy infill array DeepCore extends this to...

First search for dark matter annihilations in the Earth with the IceCube detector

We present the results of the first IceCube search for dark matter annihilation in the center of the Earth. Weakly interacting massive particles (WIMPs), candidates for dark matter, can scatter off nuclei inside the Earth and fall below its escape velocity. Over time the captured WIMPs will be accumulated and may eventually self-annihilate. Among the annihilation products only...

Searches for relativistic magnetic monopoles in IceCube

Various extensions of the Standard Model motivate the existence of stable magnetic monopoles that could have been created during an early high-energy epoch of the Universe. These primordial magnetic monopoles would be gradually accelerated by cosmic magnetic fields and could reach high velocities that make them visible in Cherenkov detectors such as IceCube. Equivalently to...