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Search: authors:"Daan J. A. Crommelin"

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Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact

Sciences, UIPS Utrecht University , Utrecht , The Netherlands 2 Lygature , Utrecht , The Netherlands 3 Daan J. A. Crommelin Public Private Partnerships (PPPs) are multiple stakeholder partnerships designed

Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine

Liposomes are versatile (sub)micron-sized membrane vesicles that can be used for a variety of applications, including drug delivery and in vivo imaging but they also represent excellent models for artificial membranes or cells. Several studies have demonstrated that in vitro transcription and translation can take place inside liposomes to obtain compartmentalized production of...

The Pharmaceutical Sciences in 2020: Report of a Conference Organized by the Board of Pharmaceutical Sciences of the International Pharmaceutical Federation (FIP)

The Board of Pharmaceutical Sciences (BPS) of the International Pharmaceutical Federation (FIP) has developed a view on the future of pharmaceutical sciences in 2020. This followed an international conference with invited participants from various fields (academicians, scientists, regulators, industrialists, venture capitalists) who shared their views on the forces that might...

Controlled Release of Octreotide and Assessment of Peptide Acylation from Poly(D,L-lactide-co-hydroxymethyl glycolide) Compared to PLGA Microspheres

Purpose To investigate the in vitro release of octreotide acetate, a somatostatin agonist, from microspheres based on a hydrophilic polyester, poly(D,L-lactide-co-hydroxymethyl glycolide) (PLHMGA). Methods Spherical and non-porous octreotide-loaded PLHMGA microspheres (12 to 16 μm) and loading efficiency of 60–70% were prepared by a solvent evaporation. Octreotide release...

Stabilization of Peptide Vesicles by Introducing Inter-Peptide Disulfide Bonds

Purpose Previously, we have shown that the amphiphilic oligopeptide SA2 (Ac-Ala-Ala-Val-Val-Leu-Leu-Leu-Trp-Glu-Glu-COOH) spontaneously self-assemble into nano-sized vesicles in aqueous environment. Relative weak individual intermolecular interactions dominate such oligopeptide assemblies. In this study we aimed at improving the stability of such peptide vesicles by covalently...

Hydrophilic Polyester Microspheres: Effect of Molecular Weight and Copolymer Composition on Release of BSA

Amir H. Ghassemi Mies J. van Steenbergen Herre Talsma Cornelus F. van Nostrum Daan J. A. Crommelin Wim E. Hennink 0 ) Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS

DNA Nuclear Targeting Sequences for Non-Viral Gene Delivery

Purpose To evaluate if introduction of DNA nuclear Targeting Sequences (DTS; i.e. recognition sequences for endogenous DNA-binding proteins) in plasmid DNA (pDNA) leads to increased transfection efficiency of non-viral gene delivery by virtue of enhanced nuclear import of the pDNA. Methods A set of DTS was identified and cloned into EGFP-reporter plasmids controlled by the CMV...