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Broncho Vaxom (OM-85) modulates rhinovirus docking proteins on human airway epithelial cells via Erk1/2 mitogen activated protein kinase and cAMP

analyses to generate Figs 2±6 as described accordingly. (PDF) Author Contributions Conceptualization: Michael Roth, Christian Pasquali, Daiana Stolz, Michael Tamm. Data curation: Michael Roth. Formal ... Roth, Michael Tamm. Resources: Christian Pasquali, Daiana Stolz. Supervision: Michael Tamm. Validation: Michael Roth. Writing ± original draft: Michael Roth, Christian Pasquali. Writing ± review

Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD—a randomised controlled study

), Thomas Sigrist (TS), Jean-Georges Frey (J-GF), Guido Domenighetti (GD) and Daiana Stolz (DS), Alexander J. Turk (AT), Andrea Azzola (AA), Ulrich Schmidt (US) and Martin Brutsche (MB) have no conflict of

Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection

Background Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with accelerated aggravation of clinical symptoms and deterioration of pulmonary function. The mechanisms by which exacerbations may contribute to airway remodeling and declined lung function are poorly understood. In this study, we investigated if AE-COPD are associated with...

Predictors of marked weight gain in a population of health care and industrial workers following smoking cessation

Background Concerns about postcessational weight gain might hamper rather than encourage smokers to quit smoking. Methods We conducted a comprehensive multi-institutional smoking cessation program for health care and industrial workers (n = 654) employed at University Hospital Basel (Switzerland) and two local health industry companies (Novartis International AG, F. Hoffmann-La...

A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM 10 exposure and diabetes

Background Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine interleukin-6 may impact on glucose homeostasis. Recent meta-analyses showed the common polymorphisms, IL6 -572G > C and IL6 -174G > C to be associated with T2D risk. These IL6...

Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study

Background Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and circulating MBL protein levels are associated with clinically relevant outcomes in the Predicting Outcome using systemic Markers In Severe Exacerbations of COPD PROMISE-COPD cohort...

Acute Effects of Aerosolized Iloprost in COPD Related Pulmonary Hypertension - A Randomized Controlled Crossover Trial

Background Inhaled iloprost potentially improves hemodynamics and gas exchange in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary hypertension (PH). Objectives To evaluate acute effects of aerosolized iloprost in patients with COPD-associated PH. Methods A randomized, double blind, crossover study was conducted in 16 COPD patients with...

Spirometer Replacement and Serial Lung Function Measurements in Population Studies: Results From the SAPALDIA Study

, Switzerland (Christian Schindler, Dirk Keidel, Nicole M. Probst-Hensch, Nino Kuenzli); University of Basel, Basel, Switzerland (Christian Schindler, Dirk Keidel, Nicole M. Probst-Hensch, Daiana Stolz, Nino ... Center Basel, Basel, Switzerland (Daiana Stolz); SAPALDIA Center Montana, Sion and Montana, Switzerland (Jean-Marie Tschopp); Medizinische Klinik Hirslanden, Aarau, Switzerland (Robert Bettschart); Hôpital

Association of Adrenal Function and Disease Severity in Community-Acquired Pneumonia

Introduction Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS – ratios in...

Aspergillus-PCR in bronchoalveolar lavage for detection of invasive pulmonary aspergillosis in immunocompromised patients

Background Invasive fungal disease (IFD) is a frequent and serious infectious complication in immunocompromised patients. Culture and cytology in bronchoalveolar lavage (BAL) have a high specificity but low sensitivity for the diagnosis of IFD as assessed by histology. Molecular methods are expected to allow a rapid diagnosis of IFD with a high sensitivity. We evaluated the...

Prognostic value of procalcitonin in respiratory tract infections across clinical settings

Alexander Kutz 0 Matthias Briel Mirjam Christ-Crain Daiana Stolz Lila Bouadma Michel Wolff Kristina B Kristoffersen Long Wei Olaf Burkhardt Tobias Welte Stefan Schroeder Vandack Nobre Michael Tamm Neera

Diagnostic value of procalcitonin, CRP, leukocytes and BAL neutrophils for pulmonary complications in the immunocompromised host

Hospital Basel , Basel, Switzerland 2 Daiana Stolz Clinic of Pneumology, University Hospital Basel , Basel, Switzerland 3 Pulmonary Medicine, University Hospital Basel , Basel, Switzerland WINNING ABSTRACT

Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia

Background Circulating levels of endothelin-1 are increased in sepsis and correlate with severity of disease. A rapid and easy immunoassay has been developed to measure the more stable ET-1 precursor peptides proET-1. The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired...

Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis

Background. Procalcitonin algorithms may reduce antibiotic use for acute respiratory tract infections (ARIs). We undertook an individual patient data meta-analysis to assess safety of this approach in different ARI diagnoses and different clinical settings. Methods. We identified clinical trials in which patients with ARI were assigned to receive antibiotics based on a...

Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia

Background Community-acquired pneumonia (CAP) is the most frequent infection-related cause of death. The reference standard to diagnose CAP is a new infiltrate on chest radiograph in the presence of recently acquired respiratory signs and symptoms. This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...

Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]

Introduction Pro-adrenomedullin (proADM) is helpful for individual risk assessment and outcome prediction in sepsis. A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP. Methods Data from 302 patients admitted to the emergency department with CAP...