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148 papers found.
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On the distance signless Laplacian spectral radius of graphs and digraphs

Let \eta(G) denote the distance signless Laplacian spectral radius of a connected graph G. In this paper,bounds for the distance signless Laplacian spectral radius of connected graphs are given, and the extremal graph with the minimal distance signless Laplacian spectral radius among the graphs with given vertex connectivity and minimum degree is determined. Furthermore, the...

Flexible semiparametric joint modeling: an application to estimate individual lung function decline and risk of pulmonary exacerbations in cystic fibrosis

Background Epidemiologic surveillance of lung function is key to clinical care of individuals with cystic fibrosis, but lung function decline is nonlinear and often impacted by acute respiratory events known as pulmonary exacerbations. Statistical models are needed to simultaneously estimate lung function decline while providing risk estimates for the onset of pulmonary...

HawkRank: a new scoring function for protein–protein docking based on weighted energy terms

Deciphering the structural determinants of protein–protein interactions (PPIs) is essential to gain a deep understanding of many important biological functions in the living cells. Computational approaches for the structural modeling of PPIs, such as protein–protein docking, are quite needed to complement existing experimental techniques. The reliability of a protein–protein...

A de novo complex chromosome rearrangement associated with multisystematic abnormalities, a case report

Complex chromosomal rearrangements (CCRs) are constitutional structural rearrangements that involve three or more chromosomes or that have more than two breakpoints. Here, we describe a four-way CCR involving chromosomes 4, 5, 6 and 8. The patient had mild multisystematic abnormalities during his development, including defects in his eyes and teeth, exomphalos and...

Selective synthesis of Fe3O4Au x Ag y nanomaterials and their potential applications in catalysis and nanomedicine

In these recent years, magnetite (Fe3O4) has witnessed a growing interest in the scientific community as a potential material in various fields of application namely in catalysis, biosensing, hyperthermia treatments, magnetic resonance imaging (MRI) contrast agents and drug delivery. Their unique properties such as metal–insulator phase transitions, superconductivity, low Curie...

Biquaternion beamspace with its application to vector-sensor array direction findings and polarization estimations

JQZ wrote the paper. DL, FX, JFJ, and JQZ reviewed and edited the manuscript. All authors read and approved the manuscript. Authors’ information Dan Li received the the M.S. and Ph.D. degrees in

Nonlinear image registration with bidirectional metric and reciprocal regularization

Nonlinear registration is an important technique to align two different images and widely applied in medical image analysis. In this paper, we develop a novel nonlinear registration framework based on the diffeomorphic demons, where a reciprocal regularizer is introduced to assume that the deformation between two images is an exact diffeomorphism. In detail, first, we adopt a...

Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages

University for their services. Author Contributions Conceptualization: Dan-Li Xie, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian-Chun Guo, X. Frank Yang, Xiao-Ping Zhong, Yong-Liang Lou ... . Data curation: Dan-Li Xie, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Jian-Chun Guo, Yong-Liang Lou. Formal analysis: Dan-Li Xie, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian

Perivascular radiofrequency renal denervation lowers blood pressure and ameliorates cardiorenal fibrosis in spontaneously hypertensive rats

YY. Formal analysis: Yunrong Zhang. Funding acquisition: SM. Investigation: SW Dan Li Yan Zhang LS. Project administration: QW DY. Resources: De Li. Supervision: SM. Writing ± original draft: SM

Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

Large purchasable screening libraries of small molecules afforded by commercial vendors are indispensable sources for virtual screening (VS). Selecting an optimal screening library for a specific VS campaign is quite important to improve the success rates and avoid wasting resources in later experimental phases. Analysis of the structural features and molecular diversity for...

Rho Kinase ROCK2 Mediates Acid-Induced NADPH Oxidase NOX5-S Expression in Human Esophageal Adenocarcinoma Cells

Mechanisms of the progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EA) are not fully understood. We have shown that NOX5-S may be involved in this progression. However, how acid upregulates NOX5-S is not well known. We found that acid-induced increase in NOX5-S expression was significantly decreased by the Rho kinase (ROCK) inhibitor Y27632 in BE mucosal...

Relationship between body mass index and depressive symptoms: the “fat and jolly” hypothesis for the middle-aged and elderly in China

authors are grateful to Kun Liu, Hong Li, Dan Li, Zhuo Chen, Li-li Zhang, and Lei-lei Guo. We thank the members of the CHARLS. Funding Collection of the CHARLS datasets used in the current study was ... Li Zhuo Chen Li-li Zhang Lei-lei Guo 0 0 Department of Surgical Nursing, School of Nursing, Jinzhou Medical University , No.40, Section 3, Songpo Road, Linghe District, Jinzhou City, Liaoning Province

Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial

Background It is becoming increasingly evident that platelet chemokines are involved in distinct aspects of atherosclerosis. The aim of this study was to examine the effects of long-term supplementation with purified anthocyanins on platelet chemokines in hypercholesterolemic individuals and to identify correlations of decreased platelet chemokine levels with serum lipid and...

SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells

Background The innate immune response of urinary tract is critically important in the defense to microbial attack. Toll-like receptor 4 (TLR4) controls initial mucosal response to uropathogenic Escherichia coli (UPEC). However, excessive and dysfunctional TLR signaling may result in severe inflammation and inappropriate tissue damage. Previous studies have demonstrated that...

Semiparametric Mixed Models for Nested Repeated Measures Applied to Ambulatory Blood Pressure Monitoring Data

Semiparametric mixed models are increasingly popular for statistical analysis of medical device studies in which long sequences of repeated measurements are recorded. Monitoring these sequences at different periods over time on the same individual, such as before and after an intervention, results in nested repeated measures (NRM). Covariance models to account for NRM and...

Clinical Nomogram for Predicting Survival Outcomes in Early Mucinous Breast Cancer

Background The features related to the prognosis of patients with mucinous breast cancer (MBC) remain controversial. We aimed to explore the prognostic factors of MBC and develop a nomogram for predicting survival outcomes. Methods The Surveillance, Epidemiology, and End Results (SEER) database was searched to identify 139611 women with resectable breast cancer from 1990 to 2007...

Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet

The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders including cancer and neurodegeneration. Although activated modestly by oxidative stress alone, robust activation of the Nrf2 defense mechanism requires the additional presence of co-factors that facilitate electron exchange. Various molecules exhibit this co-factor function, including...

Macrosomia, Perinatal and Infant Mortality in Cree Communities in Quebec, 1996-2010

Background Cree births in Quebec are characterized by the highest reported prevalence of macrosomia (~35%) in the world. It is unclear whether Cree births are at greater elevated risk of perinatal and infant mortality than other First Nations relative to non-Aboriginal births in Quebec, and if macrosomia may be related. Methods This was a population-based retrospective birth...

CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells

Background Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression in the lens epithelia in ARC. We further analyze the underlying mechanism in the...