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48 papers found.
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Numerical calculation of boundary layers and wake characteristics of high-speed trains with different lengths

with a train's increasing length. The same trend occurs in the drag coefficient of the tail car. Author Contributions Conceptualization: Dan Zhou, Jiqiang Niu. Data curation: Lirong Jia. Formal ... analysis: Lirong Jia. Investigation: Lirong Jia, Jiqiang Niu. Methodology: Jiqiang Niu. Project administration: Dan Zhou. Software: Dan Zhou. Supervision: Dan Zhou. Validation: Lirong Jia

Synthesis of 3D Hexagram-Like Cobalt–Manganese Sulfides Nanosheets Grown on Nickel Foam: A Bifunctional Electrocatalyst for Overall Water Splitting

The exploration of low-cost and efficient bifunctional electrocatalysts for oxygen evolution reaction and hydrogen evolution reaction through tuning the chemical composition is strongly required for sustainable resources. Herein, we developed a bimetallic cobalt–manganese sulfide supported on Ni foam (CMS/Ni) via a solvothermal method. It has discovered that after combining with...

Moving Model Test of High-Speed Train Aerodynamic Drag Based on Stagnation Pressure Measurements

A moving model test method based on stagnation pressure measurements is proposed to measure the train aerodynamic drag coefficient. Because the front tip of a high-speed train has a high pressure area and because a stagnation point occurs in the center of this region, the pressure of the stagnation point is equal to the dynamic pressure of the sensor tube based on the obtained...

High-Performance Flexible Asymmetric Supercapacitor Based on CoAl-LDH and rGO Electrodes

A flexible asymmetric supercapacitor (ASC) based on a CoAl-layered double hydroxide (CoAl-LDH) electrode and a reduced graphene oxide (rGO) electrode was successfully fabricated. The CoAl-LDH electrode as a positive electrode was synthesized by directly growing CoAl-LDH nanosheet arrays on a carbon cloth (CC) through a facile hydrothermal method, and it delivered a specific...

Searching for hidden-charm baryonium signals in QCD sum rules

We give an explicit QCD sum rule investigation for hidden-charm baryonium states with the quark content \(u\bar{u} d\bar{d} c\bar{c}\), spin \(J=0/1/2/3\), and of both positive and negative parities. We systematically construct the relevant local hidden-charm baryonium interpolating currents, which can actually couple to various structures, including hidden-charm baryonium states...

Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations

The ability to withstand low oxygen (hypoxia tolerance) is a polygenic and mechanistically conserved trait that has important implications for both human health and evolution. However, little is known about the diversity of genetic mechanisms involved in hypoxia adaptation in evolving populations. We used experimental evolution and whole-genome sequencing in Drosophila...

A novel variant on chromosome 6p21.1 is associated with the risk of developing colorectal cancer: a two-stage case-control study in Han Chinese

Background Genes in inflammatory pathways play a pivotal role in the development of colorectal cancer. We conducted a two-stage case-control study and aimed at screening the colorectal cancer-associated genetic variations in inflammatory genes. Methods Twenty-three candidate variants were genotyped in 952 primary colorectal cancer cases and 875 cancer-free controls from eastern...

Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke

Objective Serum soluble corin has been associated with stroke. However, whether it is associated with stroke prognosis has not yet been studied. Therefore, we aimed to study the association of serum soluble corin with risk of poor outcomes within 3 months after stroke. Methods We followed 522 stroke patients for 3 months to identify major disability, death and vascular events...

Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits

Background Population genetics predicts that tight linkage between new and/or pre-existing beneficial and deleterious alleles should decrease the efficiency of natural selection in finite populations. By decoupling beneficial and deleterious alleles and facilitating the combination of beneficial alleles, recombination accelerates the formation of high-fitness genotypes. This may...

Genomic Analysis of Detoxification Supergene Families in the Mosquito Anopheles sinensis

Anopheles sinensis is an important malaria vector in China and other Southeast Asian countries, and the emergence of insecticide resistance in this mosquito poses a serious threat to the efficacy of malaria control programs. The recently published An. sinensis genome and transcriptome provide an opportunity to understand the molecular mechanisms of insecticide resistance...

Network Analysis of Functional Brain Connectivity Driven by Gamma-Band Auditory Steady-State Response in Auditory Hallucinations

The auditory steady-state response (ASSR) may reflect activity from different regions of the brain. Particularly, it was reported that the gamma-band ASSR plays an important role in working memory, speech understanding, and recognition. Traditionally, the ASSR has been determined by power spectral density analysis, which cannot detect the exact overall distributed properties of...

Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice

Rheumatoid arthritis is a chronic degenerative autoimmune disease characterized by persistent inflammation of synovial membranes, which leads to cartilage destruction and bone erosion. To date, there are no effective therapies to slow the progress of this degenerative condition. Here, we evaluate the anti-arthritic effect of chebulanin, an abundant anti-inflammatory agent...

Purification and Characterization of Flavonoids from the Leaves of Zanthoxylum bungeanum and Correlation between Their Structure and Antioxidant Activity

Nine flavonoids were isolated and characterized from the leaves of Zanthoxylum bungeanum. Their structures were elucidated by spectroscopic techniques as quercetin (1), afzelin (2), quercitrin (3), trifolin (4), quercetin-3-O-β-D-glucoside (5), isorhamnetin 3-O-α-L-rhamnoside (6), hyperoside (7), vitexin (8) and rutin (9). All compounds were isolated from the leaves of Z...

The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys

Objectives Platensimycin (PTM) is a natural antibiotic produced by Streptomyces platensis that selectively inhibits bacterial and mammalian fatty acid synthase (FAS) without affecting synthesis of other lipids. Recently, we reported that oral administration of PTM in mouse models (db/db and db/+) with high de novo lipogenesis (DNL) tone inhibited DNL and enhanced glucose...

Central retinal artery occlusion associated with persistent truncus arteriosus and single atrium: a case report

Background Central retinal artery occlusion (CRAO) is an ocular emergency and most of the cases present with painless sudden persistent loss of vision in the range of counting fingers to perception of light. The presentation of CRAO is associated with a variety of medical conditions. We report a rare case of CRAO associated with persistent truncus arteriosus (PTA) and single...

Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys

Zhou Margaret Wu Stephen Previs Corey Miller Haiying Liu Catherine D. G. Hines Maria Madeira Jin Cao Kithsiri Herath Larry D. Spears Clay F. Semenkovich Liangsu Wang David E. Kelley Cai Li Hong- Ping

Wnt Pathway Activation Increases Hypoxia Tolerance during Development

Adaptation to hypoxia, defined as a condition of inadequate oxygen supply, has enabled humans to successfully colonize high altitude regions. The mechanisms attempted by organisms to cope with short-term hypoxia include increased ATP production via anaerobic respiration and stabilization of Hypoxia Inducible Factor 1α (HIF-1α). However, less is known about the means through which...

The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease with a diverse range of immunological and clinical manifestations. The introduction of broad spectrum immunosuppressive therapies and better management of acute disease exacerbations have improved outcomes for lupus patients over recent years. However, these regimens are burdened by substantial...

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity

Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy. However, the correlation between such activities is largely unknown. In this study, we addressed this issue in human cancer cells in response to cucurbitacin E (CuE) treatment. Our results showed that CuE induced...