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Influencing factors analysis and modeling of hospital-acquired infection in elderly patients

Hospital-acquired infection threatens the patients’ health and life and also impacts medical quality by decreasing the bed turnover rate, prolonging hospitalization, increasing hospital costs and bringing the patients the huge economic losses. Therefore, hospital infection management is the focus of today’s hospital management and one of the most prominent public health problems. ...

Fraud detections for online businesses: a perspective from blockchain technology

Background The reputation system has been designed as an effective mechanism to reduce risks associated with online shopping for customers. However, it is vulnerable to rating fraud. Some raters may inject unfairly high or low ratings to the system so as to promote their own products or demote their competitors. Method This study explores the rating fraud by differentiating the ...

A case report: Becker muscular dystrophy presenting with epilepsy and dysgnosia induced by duplication mutation of Dystrophin gene

Background Becker muscular dystrophy (BMD), a genetic disorder of X-linked recessive inheritance, typically presents with gradually progressive muscle weakness. The condition is caused by mutations of Dystrophin gene located at Xp21.2. Epilepsy is an infrequent manifestation of BMD, while cases of BMD with dysgnosia are extremely rare. Case presentation We describe a 9-year-old boy ...

Blend sign predicts poor outcome in patients with intracerebral hemorrhage

with ICH. Author Contributions Conceptualization: Qi Li, Peng Xie. Data curation: Qi Li, Wen-Song Yang, Xing-Chen Wang, Du Cao, Dan Zhu, Yang Liu, Gang Zhang, Xin Xiong, Rui Li, Yun-Xin Hu. Formal

Choroidal thickness in school children: The Gobi Desert Children Eye Study

Purpose To investigate choroidal thickness (CT) and its associations in children in a school-based study. Methods The cross-sectional school-based Gobi Desert Children Eye Study included 1565 out of 1911 (81.9%) eligible children from all schools in the oasis region of Ejina in the Gobi Desert. A detailed ophthalmic examination was performed, including spectral-domain optical ...

Pre- and Postcycloplegic Refractions in Children and Adolescents

Purpose To determine the difference between cycloplegic and non-cycloplegic refractive error and its associated factors in Chinese children and adolescents with a high prevalence of myopia. Methods A school-based study including 1565 students aged 6 to 21 years was conducted in 2013 in Ejina, Inner Mongolia, China. Comprehensive eye examinations were performed. Pre-and ...

A special issue on Biomedical Photonics

for this special issue. Dan Zhu, Shaoqun Zeng, Valery V. Tuchin Dan Zhu received her B.S. degree in physics from Hubei University (1986), M.S. degree in physical electronics from Central China Normal

Experimental transmission of Babesia microti by Rhipicephalus haemaphysaloides

Background Human babesiosis is considered an emerging threat in China. Dozens of human infections with Babesia microti have been reported recently, especially in southern China. However, the transmission vectors of this parasite in these areas are not well understood. Rhipicephalus haemaphysaloides, which is one of the dominant tick species in southern China, is a major vector of ...

Synthesis of magnetic core-branched Au shell nanostructures and their application in cancer-related miRNA detection via SERS

Magnetic core gold shell nanostructures which integrate both SERS activity and superparamagnetism are widely utilized in SERS-based detection as SERS substrates, sample separation and preconcentration operators, as well as external magnetic field controlled directional carrier. However, most of the reported gold shells coated on the magnetic cores had smooth surfaces rather than ...

Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies

Background Postmortem studies of people who have successfully committed suicide and people with depression have implicated the serotonin-1A (5-HT 1A ) receptor system in the pathophysiology of depression. Several molecular imaging studies have investigated alterations in 5-HT 1A receptors in patients with depression using positron emission tomography and have reported conflicting ...

A Genome-Wide Association Study of Field Resistance to Magnaporthe Oryzae in Rice

, Chinese Academy of Agricultural Sciences , Beijing 100193 , People's Republic of China 3 Dan Zhu, Houxiang Kang and Zhiqiang Li are co-first authors of the paper 4 Department of Plant Pathology, Ohio State

Genetic basis of sRNA quantitative variation analyzed using an experimental population derived from an elite rice hybrid

We performed a genetic analysis of sRNA abundance in flag leaf from an immortalized F2 (IMF2) population in rice. We identified 53,613,739 unique sRNAs and 165,797 sRNA expression traits (s-traits). A total of 66,649 s-traits mapped 40,049 local-sQTLs and 30,809 distant-sQTLs. By defining 80,362 sRNA clusters, 22,263 sRNA cluster QTLs (scQTLs) were recovered for 20,249 of all the ...

GsCML27, a Gene Encoding a Calcium-Binding Ef-Hand Protein from Glycine soja, Plays Differential Roles in Plant Responses to Bicarbonate, Salt and Osmotic Stresses

Calcium, as the most widely accepted messenger, plays an important role in plant stress responses through calcium-dependent signaling pathways. The calmodulin-like family genes (CMLs) encode Ca2+ sensors and function in signaling transduction in response to environmental stimuli. However, until now, the function of plant CML proteins, especially soybean CMLs, is largely unknown. ...

The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein

Background Since the identification of poly-alanine expanded poly(A) binding protein nuclear 1 (PABPN1) as the genetic cause of oculopharyngeal muscular dystrophy (OPMD), considerable progress has been made in our understanding of the pathogenesis of the disease. However, the molecular mechanisms that regulate the onset and progression of the disease remain unclear. Results In this ...

Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction

Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI) during the first week after the AMI symptoms onset, but whether catestatin is also involved in the ...

Corneal Stroma Regeneration with Acellular Corneal Stroma Sheets and Keratocytes in a Rabbit Model

Acellular corneal stroma matrix has been used for corneal stroma engineering. However, because of its compact tissue structure, regrowth of keratocytes into the scaffold is difficult. Previously, we developed a sandwich model for cartilage engineering using acellular cartilage sheets. In the present study, we tested this model for corneal stroma regeneration using acellular porcine ...

Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients

Background MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non�small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development. Methods Using real-time quantitative RT-PCR, we ...

The Positive Regulatory Roles of the TIFY10 Proteins in Plant Responses to Alkaline Stress

The TIFY family is a novel plant-specific protein family, and is characterized by a conserved TIFY motif (TIFF/YXG). Our previous studies indicated the potential roles of TIFY10/11 proteins in plant responses to alkaline stress. In the current study, we focused on the regulatory roles and possible physiological and molecular basis of the TIFY10 proteins in plant responses to ...

Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease

guidelines Dan ZHU, Gui-you LIU, Zheng LV, Shi-rong WEN, Sheng BI, and Wei-zhi WANG declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of

Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells

Aims/hypothesis Of the four exocytotic syntaxins (Syns), much is now known about the role of Syn-1A (pre-docked secretory granules [SGs]) and Syn-3 (newcomer SGs) in insulin exocytosis. Some work was reported on Syn-4’s role in biphasic glucose-stimulated insulin secretion (GSIS), but its precise role in insulin SG exocytosis remains unclear. In this paper we examine this role in ...