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Search: authors:"Dan-Li Yu"

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PEP-1-SOD1 fusion proteins block cardiac myofibroblast activation and angiotensin II-induced collagen production

Background Oxidative stress is closely associated with cardiac fibrosis. However, the effect of copper, zinc-superoxide dismutase (SOD1) as a therapeutic agent is limited due to the insufficient transduction. This study was aimed to investigate the effect of PEP-1-SOD1 fusion protein on angiotensin II (ANG II)-induced collagen metabolism in rat cardiac myofibroblasts (MCFs...