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In vitro and in vivo evaluation of docetaxel-loaded stearic acid-modified Bletilla striata polysaccharide copolymer micelles

Bletilla striata polysaccharides (BSPs) have been used in pharmaceutical and biomedical industry, the aim of the present study was to explore a BSPs amphiphilic derivative to overcome its application limit as poorly water-soluble drug carriers due to water-soluble polymers. Stearic acid (SA) was selected as a hydrophobic block to modify B. striata polysaccharides (SA-BSPs...

Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1

Microglia play important roles in extracellular matrix remodeling, tumor invasion, angiogenesis, and suppression of adaptive immunity in glioma. Na+/H+ exchanger isoform 1 (NHE1) regulates microglial activation and migration. However, little is known about the roles of NHE1 in intratumoral microglial activation and microglia–glioma interactions. Our study revealed up-regulation...

The In Situ Polymerization and Characterization of PA6/LiCl Composites

Technology Ministry of Education, Hangzhou Normal University, Hangzhou 310012, China Received 5 October 2013; Accepted 23 November 2013 Academic Editor: Yizhuang Xu Copyright © 2013 Dandan Sun et al. This

Corrosion behavior of Ti3AlC2 in molten KOH at 700 °C

This paper investigated the corrosion behaviors of Ti3AlC2 at 700 °C in molten KOH with various mass ratios. If the mass ratio of KOH:Ti3AlC2⩽2, Ti3AlC2 can resist KOH hot corrosion in 2 h. Ti3AlC2 suffered serious corrosion attack if the mass ratio⩾3. The main compositions of corroded samples were amorphous graphite and potassium titanates (K2O·nTiO2). If the samples were washed...

Preparation of Fe-Doped Nanotubes and Their Photocatalytic Activities under Visible Light

Fe-doped TiO2 nanotubes (Fe-TNTs) have been prepared by ultrasonic-assisted hydrothermal method. The structure and composition of the as-prepared TiO2 nanotubes were characterized by transmission electron microscopy, X-ray diffraction, and UV-Visible absorption spectroscopy. Their photocatalytic activities were evaluated by the degradation of MO under visible light. The UV...

Isolation and characterization of class I MHC genes in the giant panda (Ailuropoda melanoleuca)

Artificial breeding is an important project to protect, recover and reintroduce endangered species. Knowledge of the population’s genetic diversity at functional loci is important for the establishment of effective captive breeding programs. The major histocompatibility complex (MHC) genes are ideal candidate genetic markers to inform planned breeding, due to their high levels of...

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+ extrusion, cell migration and survival

Sodium–hydrogen exchanger isoform 1 (NHE1) plays a role in survival and migration/invasion of several cancers and is an emerging new therapeutic target. However, the role of NHE1 in glioblastoma and the interaction of NHE1 expression and function in glioblastoma cells with cytotoxic temozolomide (TMZ) therapy remain unknown. In this study, we detected high levels of NHE1 protein...

Stimulation of Na+/H+ Exchanger Isoform 1 Promotes Microglial Migration

Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration. NHE-1 protein was co-localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkaline intracellular pH (pHi). Chemoattractant bradykinin (BK) stimulated microglial migration by...

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration

Background The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels of NKCC1 positively correlate with the histological grade and severity of gliomas, the most common primary adult brain tumors, and up-regulated NKCC1 activity...

Sustained Na+/H+ Exchanger Activation Promotes Gliotransmitter Release from Reactive Hippocampal Astrocytes following Oxygen-Glucose Deprivation

Hypoxia ischemia (HI)-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na+/H+ exchanger...

MicroRNAs induced in melanoma treated with combination targeted therapy of Temsirolimus and Bevacizumab

Background Targeted therapies directed at commonly overexpressed pathways in melanoma have clinical activity in numerous trials. Little is known about how these therapies influence microRNA (miRNA) expression, particularly with combination regimens. Knowledge of miRNAs altered with treatment may contribute to understanding mechanisms of therapeutic effects, as well as mechanisms...

Associations of Six Single Nucleotide Polymorphisms in Obesity-Related Genes With BMI and Risk of Obesity in Chinese Children

OBJECTIVE Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs with BMI and obesity among other ethnicities are not fully described, especially in children. Among those previously...

Protection against SHIV-KB9 Infection by Combining rDNA and rFPV Vaccines Based on HIV Multiepitope and p24 Protein in Chinese Rhesus Macaques

Zeng,2 Mingyao Tian,1 Ying Jin Song,3 Ming Ye,1 Shouwen Du,1 Dayong Ren,1 Cunxia Liu,1 Na Zhu,1 Dandan Sun,1 Yi Li,1 and Ningyi Jin1 1Institute of Military Veterinary Medicine, Academy of Military

CELL BIOLOGY AND SIGNALING

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in...

LAB-CELL BIOLOGY AND SIGNALING

Glioblastoma (GBM), one of the most frequently occurring malignancies in the central nervous system, still has a very poor prognosis. To improve the prognosis of GBM patients, various attempts have been made. Immunotherapy targeting Wilms' tumor 1 (WT1) has proved to be effective in GBM (Izumoto et al. 2008). However, the functional roles of WT1 in GBM have not been intensively...