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Illness uncertainty, anxiety and depression in Chinese patients with glaucoma or cataract

(16ykjc31) and an open project of the State Key Laboratory of Ophthalmology (2016KF03). We thank all the participants who spend time attending this research. Author information Author notes Dandan Zhang ... , Sun Yat-sen University, Guangzhou, ChinaDandan Zhang, Zhigang Fan, Xinbo Gao, Wenmin Huang, Qiongman Yang, Zhongwen Li, Mingkai Lin, Huiming Xiao & Jian Ge AuthorsSearch for Dandan Zhang in:Nature

miR-199a modulates cisplatin resistance in ovarian cancer by targeting Hif1α

miR-199a modulates cisplatin resistance in ovarian cancer by targeting Hif1alpha Xue Feng,1 Ning Liu,2 Suo Deng,1 Dandan Zhang,1 Kexin Wang,1 Meisong Lu1 1Department of Obstetrics and Gynecology

Face-body integration of intense emotional expressions of victory and defeat

Human facial expressions can be recognized rapidly and effortlessly. However, for intense emotions from real life, positive and negative facial expressions are difficult to discriminate and the judgment of facial expressions is biased towards simultaneously perceived body expressions. This study employed event-related potentials (ERPs) to investigate the neural dynamics involved...

Gamma-glutamyltransferase and risk of cardiovascular mortality: A dose-response meta-analysis of prospective cohort studies

Background Serum gamma-glutamyltransferase (GGT) elevation likely contributes to cardiovascular (CV) mortality, however it has remained unknown whether a dose-response relationship exists between serum GGT and CV mortality. Methods We searched the PubMed, EMBASE, and Cochrane library databases for prospective cohort studies published up to October 2, 2016. Summary hazard ratios...

Enhanced metabolic process to indole alkaloids in Clematis terniflora DC. after exposure to high level of UV-B irradiation followed by the dark

Background Indole alkaloids, which characteristically contain an indole nucleus, have pharmaceutical potential in a diverse range of applications. UV-B can elicit the accumulation of indole alkaloids. The indole alkaloid (6-hydroxyl-1H-indol-3-yl) carboxylic acid methyl ester with cytotoxic activity was found to accumulate in Clematis terniflora DC. leaves after exposure to high...

Mechanisms for attentional modulation by threatening emotions of fear, anger, and disgust

Appropriately attending to threatening environmental stimuli is evolutionarily adaptive and crucial for survival. This study revealed that nonconscious attentional modulation of disgust has different behavioral and event-related potential (ERP) patterns, as compared to fear and anger. To facilitate its evolutionary purpose of avoidance, disgust first diverts rather than attracts...

The Salinity Responsive Mechanism of a Hydroxyproline-Tolerant Mutant of Peanut Based on Digital Gene Expression Profiling Analysis

Soil salinity seriously limits plant growth and yield. Strategies have been developed for plants to cope with various environmental stresses during evolution. To screen for the broad-spectrum genes and the molecular mechanism about a hydroxyproline-tolerant mutant of peanut with enhanced salinity resistance under salinity stress, digital gene expression (DGE) sequencing was...

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance DanDan Zhang,1 Yan Yan Kong,1 Jia Hui Sun,1 Shao Jie Huo,1 Min Zhou,2 Yi

Solutions of semiclassical states for perturbed p-Laplacian equation with critical exponent

In this paper, we study semiclassical states for perturbed p-Laplacian equations. Under some given conditions and minimax methods, we show that this problem has at least one positive solution provided that ε ≤ E ; for any m ∈ N , it has m pairs of solutions if ε ≤ E m , where ℰ, E m are sufficiently small positive numbers. Moreover, these solutions u ε → 0 in W 1 , p ( R N ) as...

Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma

Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma Ying Liu,1,* Xin Wu,1,* Yuan Gao,2,* Jigang Zhang,1 Dandan

Enhanced thermal stability of lichenase from Bacillus subtilis 168 by SpyTag/SpyCatcher-mediated spontaneous cyclization

Background SpyTag is a peptide that can form an irreversible covalent linkage to its 12 kDa partner SpyCatcher via a spontaneous isopeptide bond. Herein, we fused SpyTag at the N-terminal of lichenase and SpyCatcher at C-terminal so that the termini of lichenase were locked together by the covalent interaction between the partners. In addition, an elastin-like polypeptides tag...

A novel variant on chromosome 6p21.1 is associated with the risk of developing colorectal cancer: a two-stage case-control study in Han Chinese

Background Genes in inflammatory pathways play a pivotal role in the development of colorectal cancer. We conducted a two-stage case-control study and aimed at screening the colorectal cancer-associated genetic variations in inflammatory genes. Methods Twenty-three candidate variants were genotyped in 952 primary colorectal cancer cases and 875 cancer-free controls from eastern...

Long Noncoding RNA miR210HG as a Potential Biomarker for the Diagnosis of Glioma

Background Glioma remains a diagnostic challenge because of its variable clinical presentation and a lack of reliable screening tools. Long noncoding RNAs (lncRNAs) regulate gene function in a wide range of pathophysiological processes and are therefore emerging biomarkers for prostate cancer, hepatic cancer, and other tumor diseases. However, the effective use of lncRNAs as...

MicroRNA-410-5p as a potential serum biomarker for the diagnosis of prostate cancer

diagnose PCa. Authors’ contributions Jiaqi Wang and Dandan Zhang carried out the molecular biology studies, participated in the RNA extraction, miRNA reverse transcription and qPCR. Shanrong Liu, Jiaqi wang

Resistance to Bacillus thuringiensis Mediated by an ABC Transporter Mutation Increases Susceptibility to Toxins from Other Bacteria in an Invasive Insect

Evolution of pest resistance reduces the efficacy of insecticidal proteins from the gram-positive bacterium Bacillus thuringiensis (Bt) used widely in sprays and transgenic crops. Recent efforts to delay pest adaptation to Bt crops focus primarily on combinations of two or more Bt toxins that kill the same pest, but this approach is often compromised because resistance to one Bt...

Single-trial ERP evidence for the three-stage scheme of facial expression processing

Using a rapid serial visual presentation paradigm, we previously showed that the average amplitudes of six event-related potential (ERP) components were affected by different categories of emotional faces. In the current study, we investigated the six discriminating components on a single-trial level to clarify whether the amplitude difference between experimental conditions...

Spatial Attention Effects of Disgusted and Fearful Faces

Effective processing of threat-related stimuli is of significant evolutionary advantage. Given the intricate relationship between attention and the neural processing of threat-related emotions, this study manipulated attention allocation and emotional categories of threat-related stimuli as independent factors and investigated the time course of spatial-attention-modulated...