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A Review of Recent Advances Using Tocilizumab in the Treatment of Rheumatic Diseases

of the submitted work. Daniel E. Furst reports grant/research support from AbbVie, Actelion, Amgen, BristolMyers Squibb, Corbus, National Institutes of Health, Novartis, Pfizer, and Roche/Genentech and

Review of Routine Laboratory Monitoring for Patients with Rheumatoid Arthritis Receiving Biologic or Nonbiologic DMARDs

demonstrated. These questions are ones that we await answers to in the coming years. Conflicts of Interest William F. C. Rigby has acted as a consultant for Roche/Genentech; Daniel E. Furst has received grant

Misalignment between physicians and patient satisfaction with psoriatic arthritis disease control

The main objective of the present study is to evaluate the misalignment between psoriatic arthritis (PsA) patient- and physician-reported satisfaction with PsA control. Data came from the Adelphi Rheumatology Disease Specific Programme, a retrospective, cross-sectional survey of US-based rheumatologists and patients. Physicians provided satisfaction and clinical characteristics...

Safety and feasibility of umbilical cord mesenchymal stem cells in treatment-refractory systemic lupus erythematosus nephritis: time for a double-blind placebo-controlled trial to determine efficacy

trial to deter- mine efficacy Thasia G Woodworth 0 Daniel E Furst 0 0 Division of Rheumatology, David Geffen School of Medicine, University of California , Los Angeles, CA , USA As translational

Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis: A Meta-Research Project

Background Sponsors that seek to commercialize new drugs apply to the Food and Drug Administration (FDA) which independently analyzes the raw data and reports the results on its website. Objectives This study sought to determine if there are differences between the FDA assessments and journal reports on biologic agents developed for the treatment of rheumatoid arthritis. Methods...

Most Trial Eligibility Criteria and Patient Baseline Characteristics Do Not Modify Treatment Effect in Trials Using Targeted Therapies for Rheumatoid Arthritis: A Meta-Epidemiological Study

Objective To determine if variations in trial eligibility criteria and patient baseline characteristics could be considered effect modifiers of the treatment response when testing targeted therapies (biological agents and targeted synthetic disease modifying antirheumatic drugs (DMARDs)) for rheumatoid arthritis (RA). Methods We conducted a meta-epidemiological study of all...

Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations

, Virginia D. Steen, Barri J. Fessler, Dinesh Khanna, Elena Schiopu, Richard M. Silver, Jerry A. Molitor, Daniel E. Furst, Suzanne Kafaja, Robert W. Simms, Robert A. Lafyatis, Patricia Carreira, Carmen Pilar ... Acosta-Herrera, Peter K. Gregersen, Annette T. Lee, Virginia D. Steen, Barri J. Fessler, Dinesh Khanna, Elena Schiopu, Richard M. Silver, Jerry A. Molitor, Daniel E. Furst, Suzanne Kafaja, Robert W. Simms

Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year

Introduction Clinical trials of new treatments for rheumatoid arthritis (RA) typically require subjects to have an elevated acute phase reactant (APR), in addition to tender and swollen joints. However, despite the elevation of individual components of the Clinical Disease Activity Index (CDAI) (tender and swollen joint counts and patient and physician global assessment), some...

An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results

Preliminary Results Marie Hudson,1 Murray Baron,1 Ernest Lo,1 Joanna Weinfeld,1 Daniel E. Furst,2 and Dinesh Khanna2 1Jewish General Hospital and McGill University, Montreal, QC, Canada H3T 1E2 2Geffen School ... ; Daniel E. Furst (1): UCLA, Los Angeles, California, USA; Jean Cabane (1): Hôpital Saint-Antoine, Paris, France; Mary Ellen Csuka (1): Medical College Wisconsin, Milwaukee, Wisconsin, USA; Eric Hachulla (1

Clinical trials in systemic sclerosis: lessons learned and outcomes

The pathogenesis of systemic sclerosis (SSc) is complex and largely unclear. The clinical heterogeneity of the disease and its progression over a number of years makes the choice of endpoints in the design of clinical trials difficult. The overwhelming need in this disease is to diagnose it early and identify those patients who will benefit most from early, aggressive treatment...

The utility of MRI in predicting radiographic erosions in the metatarsophalangeal joints of the rheumatoid foot: a prospective longitudinal cohort study

Introduction Magnetic resonance imaging (MRI) may reveal rheumatoid arthritis (RA) changes in the feet when hands are normal. The purpose of this study was to determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of a metatarsophalangeal (MTP) erosion on MRI to predict a subsequent radiographic erosion in the same joint...

Systemic sclerosis-associated pulmonary hypertension: why disease-specific composite endpoints are needed

Christopher P Denton 0 Jerome Avouac Frank Behrens Daniel E Furst Ivan Foeldvari Marc Humbert DoerteHuscher Otylia Kowal-Bielecka Marco Matucci-Cerinic Peter Nash Christian F Opitz David Pittrow

Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

BackgroundScleroderma is an autoimmune disease with a characteristic vascular pathology. The vasculopathy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease.Methodology/Principal FindingsWe used immunohistochemical and mRNA in situ hybridization techniques to characterize this vasculopathy and showed with morphometry that...