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Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual...

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual...

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual...

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual...

Once-Monthly Continuous Erythropoietin Receptor Activator (C.E.R.A.) in Patients with Hemodialysis-Dependent Chronic Kidney Disease: Pooled Data from Phase III Trials

Introduction Erythropoiesis-stimulating agents and iron are commonly used in patients with chronic kidney disease with the aim of correcting anemia and maintaining stable hemoglobin levels. We analyzed pooled data from 13 studies with similar designs included in the Umbrella Continuous Erythropoietin Receptor Activator (C.E.R.A.) program to investigate the effects of continuous...

Impact of individual intravenous iron preparations on the differentiation of monocytes towards macrophages and dendritic cells

Background Treatment of iron deficiency with intravenous (i.v.) iron is a first-line strategy to improve anaemia of chronic kidney disease. Previous in vitro experiments demonstrated that different i.v. iron preparations inhibit differentiation of haematopoietic stem cells to monocytes, but their effect on monocyte differentiation to macrophages and mature dendritic cells (mDCs...

Effective Achievement of Hemoglobin Stability with Once-Monthly C.E.R.A. in Peritoneal Dialysis Patients: A Prospective Study

; Tilman David-Walek, Kiel; Ralf Desselberger, Greifswald; Robert Dunst, Reut-lingen; Hans-Herbert Echterhoff, Bielefeld; Danilo Fliser, Homburg; Bjo rn Friedrich, Leonberg; Christian Friedrichsohn

Uraemic dyslipidaemia revisited: role of high-density lipoprotein

Chronic kidney disease (CKD) is accompanied by strong cardiovascular risk. In a rather rigid picture of lipoprotein biology, low-density lipoprotein (LDL) is referred to as ‘bad cholesterol’, while high-density lipoprotein (HDL) is referred to as ‘good cholesterol’. However, recent experimental evidence suggests that HDL may be rendered dysfunctional regarding its effects on the...

The gap between calculated and actual calcium substitution during citrate anticoagulation in an immobilised patient on renal replacement therapy reflects the extent of bone loss – a case report

therapy; CVVHD: Continuous venovenous haemodialysis; HU: Hounsfield units. Competing interests Matthias Klingele received speaker fees from Fresenius Medical Care and Baxter. Danilo Fliser received

FGF-23: the rise of a novel cardiovascular risk marker in CKD

Gunnar H. Heine 0 Sarah Seiler 0 Danilo Fliser 0 0 Department of Internal Medicine IV-Nephrology and Hypertension, Saarland University Medical Center , Homburg/Saar , Germany Elevated plasma levels

Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients

Background Graft survival in transplant recipients depends on pharmacokinetics and on individual susceptibility towards immunosuppressive drugs. Nevertheless, pharmacodynamic changes in T-cell functionality in response to drugs and in relation to pharmacokinetics are poorly characterized. We therefore investigated the immunosuppressive effect of calcineurin inhibitors and...

Immunosuppression and monocyte subsets

Background Monocytes are critical in innate immunity and transplantation. Three monocyte subsets exist, CD14++CD16−, CD14++CD16+ and CD14+CD16++ monocytes; cell counts of CD14++CD16+ and CD14+CD16++ monocytes are increased in pre-transplant chronic kidney disease. Interestingly, the effect of immunosuppressants on monocyte heterogeneity has not been well studied.

PCSK9 Plasma Concentrations Are Independent of GFR and Do Not Predict Cardiovascular Events in Patients with Decreased GFR

Background Impaired renal function causes dyslipidemia that contributes to elevated cardiovascular risk in patients with chronic kidney disease (CKD). The proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of the LDL receptor and plasma cholesterol concentrations. Its relationship to kidney function and cardiovascular events in patients with reduced glomerular...

Distinct immunologic effects of different intravenous iron preparations on monocytes

Background Iron deficiency contributes to anaemia in patients with chronic kidney disease. I.v. iron is therefore widely used for anaemia treatment, although it may induce oxidative stress and activate monocytes. Different i.v. iron preparations are available, but interestingly their substance-specific immunologic effects are poorly studied.

A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

Introduction Several scoring systems have been developed to predict postoperative mortality and complications in patients undergoing cardiac surgery. However, these computer-based calculations are time- and cost-intensive. A simple but highly predictive test for postoperative risk would be of clinical benefit with respect to increasingly scarce hospital resources. We therefore...

The fate of triaged and rejected manuscripts

9 10 11 12 13 14 15 16 24 Graziella D'arrigo 0 8 9 10 11 12 13 14 15 16 19 Pieter Evenepoel 0 8 9 10 11 12 13 14 15 16 23 Danilo Fliser 0 8 9 10 11 12 13 14 15 16 22 Jonathan Fox 0 8 9 10 11 12 13 14

The plasticity of progenitor cells—why is it of interest to the nephrologists?

Ferdinand H. Bahlmann 0 Danilo Fliser 0 0 Department of Medicine IV, University of the Saarland , Homburg/Saar, Germany C The Author [2009]. Published by Oxford University Press on behalf of ERA