Search: authors:"David A. Ehrmann"

Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However, the precise mechanisms of metformin action in PCOS remain...

Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism

Objectives: Obstructive sleep apnea (OSA) is more prevalent in men and is an independent risk factor for type 2 diabetes. We aimed to determine if there are sex differences in the impact of OSA on glucose metabolism in nondiabetic overweight and obese adults.Methods: One hundred and forty-five men and women (age 33.4 ± 0.6, BMI 37.2 ± 0.7, 70.3% blacks) from the community...

Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test

BACKGROUND Polycystic ovary syndrome (PCOS) patients typically have 17-hydroxyprogesterone (17OHP) hyperresponsiveness to GnRH agonist (GnRHa) (PCOS-T). The objective of this study was to determine the source of androgen excess in the one-third of PCOS patients who atypically lack this type of ovarian dysfunction (PCOS-A).

Sleep Disturbances and Their Relationship to Glucose Tolerance in Pregnancy

SIRIMON REUTRAKUL CDE NAUSHEEN ZAIDI KRISTEN WROBLEWSKI MS HELEN H. KAY MAHMOUD ISMAIL DAVID A. EHRMANN EVE VAN CAUTER PHD C a r d i o v a s c u l a r OBJECTIVEdTo explore relationships among sleep

Factors Associated With Diabetes Onset During Metformin Versus Placebo Therapy in the Diabetes Prevention Program

In the Diabetes Prevention Program, treatment of subjects with impaired glucose tolerance with metformin >3.2 years reduced the risk of developing type 2 diabetes by 30% compared with placebo. This study describes the mechanisms of this effect. In proportional hazards regression models with 2,155 subjects, changes in weight, the insulinogenic index (IGR), fasting insulin, and...

Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Urbanek 9 10 David A. Ehrmann 12 Loren L. Armstrong 9 Ji Young Lee 9 Ryan Sisk 9 Tugce Karaderi 13 Thomas M. Barber 14 Mark I. McCarthy 13 15 16 Stephen Franks 17 Cecilia M. Lindgren 13 19 Corrine K. Welt 0 ... secretion in European ancestry populations M. Geoffrey Hayes, Margrit Urbanek, David A. Ehrmann, Loren L. Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, Thomas M. Barber, Mark I. McCarthy, Stephen Franks