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11 papers found.
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Making Integrated Multimodal Pain Care a Reality: A Path Forward

. Our responsibility is to support the implementation of what we know, even as we develop better evidence about what we do not yet know. Corresponding Author: David Atkins, MD, MPH; Office of Research and

Health Services Research on Women Veterans: A Critical Partner on the Road to Patient-Centered Care

David Atkins ) 0 0 Department of Veterans Affairs, Office of Research and Development, Health Services Research and Development Service (10P9H) , Washington, DC, USA - S womens military

QUERI and implementation research: Emerging from adolescence into adulthood: QUERI Series

The Quality Enhancement Research Initiative (QUERI) program and implementation research have both come of age in the 10 years since QUERI was established. Looking forward, if QUERI and the field of implementation science are to mature successfully, we will need to address a series of challenges. First, we need to more clearly demonstrate how applying principles of implementation...

Connecting Research and Patient Care: Lessons from the VA’s Quality Enhancement Research Initiative

David Atkins 0 0 Department of Veterans Affairs, Health Services Research and Development Service (124Q) , Washington, DC, USA - T in a complex health system continues to be a vexing one. he

A rapid genetic screening system for identifying gene-specific suppression constructs for use in human cells

We describe a rapid cell-based genetic screen using fission yeast for identifying efficient gene suppression constructs (GSCs) from large libraries (105) for any target sequence for use in human cells. In this system, target sequences are fused to the 5′ end of the lacZ reporter gene and expressed in yeast. Random fragment expression libraries derived from the target sequence are...

Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

Background Farnesyl protein transferase inhibitors (FTIs) were originally developed to inhibit oncogenic ras, however it is now clear that there are several other potential targets for this drug class. The FTI tipifarnib (ZARNESTRA™, R115777) has recently demonstrated clinical responses in adults with refractory and relapsed acute leukemias. This study was conducted to identify...

Genetic Test Evaluation: Information Needs of Clinicians, Policy Makers, and the Public

Growing knowledge about gene-disease associations will lead to new opportunities for genetic testing. Many experts predict that genetic testing will become increasingly important as a guide to prevention, clinical management, and drug treatment based on genetic susceptibilities. As part of a Human Genetic Epidemiology workshop convened by the Centers for Disease Control and...

Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group

Background A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and communicate this information so that it can easily be understood and thereby help people make well-informed decisions. Our...

Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system

Background Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key shortcomings in these systems. The aim of this study was to pilot test and further develop the GRADE approach to grading evidence...