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The sequence of disease-modifying therapies in relapsing multiple sclerosis: safety and immunologic considerations

Virginia School of Medicine , PO Box 800394, Charlottesville, VA 22908 , USA 1 David E. Jones 2 Gabriel Pardo The treatment landscape for relapsing forms of multiple sclerosis (RMS) has expanded

Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome

Background Post exertional muscle fatigue is a key feature in Chronic Fatigue Syndrome (CFS). Abnormalities of skeletal muscle function have been identified in some but not all patients with CFS. To try to limit potential confounders that might contribute to this clinical heterogeneity, we developed a novel in vitro system that allows comparison of AMP kinase (AMPK) activation and ...

Automatic Extraction of Nanoparticle Properties Using Natural Language Processing: NanoSifter an Application to Acquire PAMAM Dendrimer Properties

In this study, we demonstrate the use of natural language processing methods to extract, from nanomedicine literature, numeric values of biomedical property terms of poly(amidoamine) dendrimers. We have developed a method for extracting these values for properties taken from the NanoParticle Ontology, using the General Architecture for Text Engineering and a Nearly-New Information ...

A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome

Background Fatigue is a debilitating condition with a significant impact on patients’ quality of life. Fatigue is frequently reported by patients suffering from primary Sjögren’s Syndrome (pSS), a chronic autoimmune condition characterised by dryness of the eyes and the mouth. However, although fatigue is common in pSS, it does not manifest in all sufferers, providing an excellent ...

FilmArray, an Automated Nested Multiplex PCR System for Multi-Pathogen Detection: Development and Application to Respiratory Tract Infection

The ideal clinical diagnostic system should deliver rapid, sensitive, specific and reproducible results while minimizing the requirements for specialized laboratory facilities and skilled technicians. We describe an integrated diagnostic platform, the “FilmArray”, which fully automates the detection and identification of multiple organisms from a single sample in about one hour. An ...

Archaeometry Applied to Olmec Iron-Ore Beads

Mmeessooaammeerriiccaa steven E jones samuel T jones and david E jones archaeometry is the use of advanced physical methods in the study of archaeology the tools of applied physics allow us to search for clues contained ... BYU office of research and creative activities steven E jones is professor of physics at brigham young university samuel T jones is a graduate of brigham young university in physics david E jones is a

The integral divalent cation within the intermolecular purine*purine·pyrimidine structure: a variable determinant of the potential for and characteristics of the triple helical association

In vitro assembly of an intermolecular purine*purine· pyrimidine triple helix requires the presence of a divalent cation. The relationships between cation coordination and triplex assembly were investigated, and we have obtained new evidence for at least three functionally distinct potential modes of divalent cation coordination. (i) The positive influence of the divalent cation on ...