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A role for the spindle assembly checkpoint in the DNA damage response

and Molecular Biology, Universitat Autonoma de Barcelona , Bellaterra, 08193 Catalonia , Spain 1 Communicated by M. Kupiec 2 David G. Quintana Spontaneous DNA damage poses a continuous threat to

Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast

A surveillance mechanism, the S phase checkpoint, blocks progression into mitosis in response to DNA damage and replication stress. Segregation of damaged or incompletely replicated chromosomes results in genomic instability. In humans, the S phase checkpoint has been shown to constitute an anti-cancer barrier. Inhibition of mitotic cyclin dependent kinase (M-CDK) activity by Wee1 ...