Advanced search    

Search: authors:"David G. Quintana"

2 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

A role for the spindle assembly checkpoint in the DNA damage response

and Molecular Biology, Universitat Autonoma de Barcelona , Bellaterra, 08193 Catalonia , Spain 1 Communicated by M. Kupiec 2 David G. Quintana Spontaneous DNA damage poses a continuous threat to

Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast

A surveillance mechanism, the S phase checkpoint, blocks progression into mitosis in response to DNA damage and replication stress. Segregation of damaged or incompletely replicated chromosomes results in genomic instability. In humans, the S phase checkpoint has been shown to constitute an anti-cancer barrier. Inhibition of mitotic cyclin dependent kinase (M-CDK) activity by...