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8 papers found.
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Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics

. 0 School of Medicine, University of Leeds , LIGHT Building, Clarendon Way, Leeds LS2 9JT, England , UK 1 David J. Beech Novel approaches towards cancer therapy are urgently needed. One approach might

Orai1 calcium channels in the vasculature

David J Beech 0 0 D. J. Beech Multidisciplinary Cardiovascular Research Centre, University of Leeds , Leeds LS2 9JT, UK 1 ) Faculty of Biological Sciences, University of Leeds , Garstang Building

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells

Ching-On Wong Piruthivi Sukumar David J. Beech Xiaoqiang Yao 0 ) Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds , Leeds LS2 9JT, UK TRPC5 is a

TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells

Background Transient Receptor Potential Canonical 1 (TRPC1) is a widely-expressed mammalian cationic channel with functional effects that include stimulation of cardiovascular remodelling. The initial aim of this study was to investigate variation in TRPC1-encoding gene transcripts. Results Extensive TRPC1 transcript alternative splicing was observed, with exons 2, 3 and 5-9 ...

Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction

Piruthivi Sukumar Hema Viswambharan Helen Imrie Richard M. Cubbon Nadira Yuldasheva Matthew Gage Stacey Galloway Anna Skromna Parkavi Kandavelu Celio X. Santos V. Kate Gatenby Jessica Smith David J ... . Beech Stephen B. Wheatcroft Keith M. Channon Ajay M. Shah Mark T. Kearney Insulin resistance is characterized by excessive endothelial cell generation of potentially cytotoxic concentrations of reactive

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

Keith M. Channon David J. Beech Stephen B. Wheatcroft Mark T. Kearney OBJECTIVE-In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R+/2), at a whole-body level, increases resistance to inflammation

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

Xuan V. Kate Gatenby Peter J. Grant Keith M. Channon David J. Beech Stephen B. Wheatcroft Mark T. Kearney - We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium

Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism

The ATP-sensitive potassium (KATP) channel controls insulin secretion by coupling glucose metabolism to excitability of the pancreatic β-cell membrane. The channel comprises four subunits each of Kir6.2 and the sulphonylurea receptor (SUR1), encoded by KCNJ11 and ABCC8, respectively. Mutations in these genes that result in reduced activity or expression of KATP channels lead to ...