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Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol

Despite advances in treatment, acute myocardial infarction (MI) is still associated with significant morbidity and mortality, especially in patients with extensive damage and scar formation. Based on some promising preclinical studies, there is interest in the use of mesenchymal stromal cells (MSCs) to promote cardiac repair after acute MI. However, there is a need for a...

Can we create a Canadian Perioperative Anesthesia Clinical Trials Group? We review the first five years and glimpse into the future

• Scott Beattie, University of Toronto Hilary P. Grocott, University of Manitoba C. David Mazer, St. Michael’s Hospital, University of Toronto Alexis F. Turgeon, Universite´ Laval Andre´ Denault ... Annexe: *Membres actuels du Comite´ de pilotage Richard Hall, Executive Chair, Dalhousie University Scott Beattie, University of Toronto Hilary P. Grocott, University of Manitoba C. David Mazer, St

Evaluation of TAPSE as a measure of right ventricular output

, the acquisition and interpretation of data, as well as the drafting and revision of all versions prior to submission. He also approved the final draft. C. David Mazer made a significant contribution

Review article: Risks of anemia and related management strategies: can perioperative blood management improve patient safety?

Division of Hematology, Department of Medicine, St. Michael's Hospital, University of Toronto , Toronto, ON , Canada 1 G. M. T. Hare, MD , PhD C. David Mazer, MD Department of Physiology, University of ... Toronto , Toronto, ON , Canada 2 G. M. T. Hare, MD , PhD C. David Mazer, MD Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of

“Seizing” the opportunity to understand antifibrinolytic drugs

, Canada 1 I. Lecker, BSc Department of Physiology, University of Toronto , Toronto, ON, Canada 2 C. David Mazer has received research funding and/or honoraria from NovoNordisk , Cubist, Bayer, The Medicines

The “sticky” business of “adherence” to transfusion guidelines

Alan T. Tinmouth Gregory M. T. Hare C. David Mazer - and that these differences appear to be greater for non- the inappropriate transfusion rate increases to 32.9%. This red-cell transfusions

Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery: a prospective observational study

Francoise Briet Rosane Nisenbaum Alexander D Romaschin C David Mazer 0 Department of Critical Care and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto , 4-054C Queen Wing

Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study

PurposeAcute kidney injury (AKI) is a potentially serious complication of cardiac surgery. Anemia and red blood cell (RBC) transfusion have individually been identified as potentially modifiable risk factors, but their interrelationship with AKI has not been clearly defined. The purpose of this study was to explore the interrelationship of preoperative anemia, intraoperative...

Optimizing transfusion practice

Nadine Shehata MSC FRCPC C. David Mazer FRCPC Tchallenges and the realization that blood RANSFUSION therapy has undergone several changes over the years with supply transfusions are not innocuous

Induction of anesthesia does not alter tricuspid annular velocities: a tissue Doppler assessment

Purpose In this prospective observational cohort study, we investigated whether tricuspid annular velocities (TAV) are altered after induction of anesthesia in patients undergoing coronary artery bypass graft (CABG) surgery. Methods Twenty-four elective CABG patients were assessed before and after induction of anesthesia, and a convenience sample of nine healthy volunteers was...

Perioperative management of acute and chronic anemia: has the pendulum swung too far?

0 G. M. T. Hare, MD , PhD C. D. Mazer, MD Department of Physiology, University of Toronto , Toronto, ON, Canada 1 Gregory M. T. Hare, MD , PhD James E. Baker, MD C. David Mazer, MD Anemiaand its

The rationale for platelet transfusion during cardiopulmonary bypass: an observational study

, Ashley Joseph, and Nadine Shehata contributed to drafting the manuscript. Nusrat Zaffar, Ashley Joseph C. David Mazer , Rosane Nisenbaum Keyvan Karkouti, Alan Tinmouth, Mark Peterson, Katerina Pavenski ... , Jeannie Callum , Christine Cserti-Gazdewich, and Nadine Shehata contributed to the revision of the manuscript. C. David Mazer and Nadine Shehata contributed to the conception of the study. C. David Mazer

Universal tranexamic acid therapy to minimize transfusion for major joint arthroplasty: a retrospective analysis of protocol implementation

, Alexander Ho, Emil H. Schemitsch, Nick Lo, Earl R. Bogoch, Antoine Pronovost, Rosa Maria Tanzini, C. David Mazer, John Freedman, and Gregory M.T. Hare made substantial contributions to the conception and ... Howell, Emil H. Schemitsch, Nick Lo, Earl R. Bogoch, Antoine Pronovost, Albert K.Y. Tsui, Rosa Maria Tanzini, Robisa Pulendrarajah, C. David Mazer, John Freedman, and Gregory M.T. Hare contributed to the

Plasma methemoglobin as a potential biomarker of anemic stress in humans

research, performed the research, contributed novel intellectual input, analyzed the data, and wrote the paper. C. David Mazer designed the research, performed the research, contributed novel intellectual

Sternal plating for primary and secondary sternal closure; can it improve sternal stability?

Background Sternal instability with mediastinitis is a very serious complication after median sternotomy. Biomechanical studies have suggested superiority of rigid plate fixation over wire cerclage for sternal fixation. This study tests the hypothesis that sternal closure stability can be improved by adding plate fixation in a human cadaver model. Methods Midline sternotomy was...