. Jones 0 Gavin P. Andrews 0 0 Pharmaceutical Engineering Group, School of Pharmacy, Medical Biology Centre, Queen's University , Belfast, BT9 7BL, Northern Ireland , UK The aim of this article was to
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Omar A Khan 0 Richard Guerrant James Sanders Charles Carpenter Margaret Spottswood David S Jones Cliff O'Callahan Timothy F Brewer Jeffrey F Markuns Stephen Gillam Joseph O'Neill Neal Nathanson
Scientists and experts in science policy have become increasingly interested in strengthening translational research. Efforts to understand the nature of translational research and monitor policy interventions face an obstacle: how can translational research be defined in order to facilitate analysis of it? We describe methods of scientometric analysis that can do this. We...
Background Scientists and experts in science policy have become increasingly interested in strengthening translational research. Efforts to understand the nature of translational research and monitor policy interventions face an obstacle: how can translational research be defined in order to facilitate analysis of it? We describe methods of scientometric analysis that can do this...
By carrying out oligonucleotide-directed mutagenesis, in vitro, on a 3.3 kb XhoI-HindIII fragment from Moloney murine leukaemia virus Mo-MuLV proviral DNA, inserted into the phagemid pTZ19R, nine separate fragments have been prepared in which mutations have been inserted at and around the gag-pol gene junction. Using these mutant fragments Mo-MuLV proviral DNA has been...
in writing and review of this manuscript. This work was supported by the Intramural Research Program of the National Institutes of Health. Author Contributions Conceptualization: David S. Jones ... . Supervision: Puthupparampil V. Scaria, David L. Narum, Patrick E. Duffy. Validation: David S. Jones. Writing ± original draft: Puthupparampil V. Scaria. Writing ± review & editing: Patrick E. Duffy. 15 / 19
We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and glucose from skin in vitro and in vivo. MN prepared from aqueous blends of hydrolysed poly(methyl-vinylether-co-maleic anhydride) (11.1% w/w) and poly(ethyleneglycol) 10,000 daltons (5.6% w/w) and crosslinked by...
A practical method is described for synthesizing conjugated protein nanoparticles using thioether (thiol-maleimide) cross-linking chemistry. This method fills the need for a reliable and reproducible synthesis of protein conjugate vaccines for preclinical studies, which can be adapted to produce comparable material for clinical studies. The described method appears to be...
Hospital-acquired infections pose both a major risk to patient wellbeing and an economic burden on global healthcare systems, with the problem compounded by the emergence of multidrug resistant and biocide tolerant bacterial pathogens. Many inanimate surfaces can act as a reservoir for infection, and adequate disinfection is difficult to achieve and requires direct intervention...
Purpose To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2-methyoxyethyl acrylate) (pMEA) scaffold. Methods Flurbiprofen- and naproxen-DMB conjugates were prepared via esterification and characterised via NMR spectroscopy and mass spectrometry following...
By David S. Jones, Published on 01/01/12 ... - Consequences of the Disparity Between U.S. and E.U. Treatment of Communications From In-House Attorneys After Akzo-Nobel David S. Jones* INTRODUCTION Suppose that a South Carolina attorney provides solicited