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Information on blinding in registered records of clinical trials

Information on blinding is part of the data that should be provided upon registration of a trial at a clinical trials registry. Reporting of blinding is often absent or of low quality in published articles of clinical trials. This study researched the presence and quality of information on blinding in registered records of clinical trials and highlights the important role of data...

The Quality of Registration of Clinical Trials: Still a Problem

Introduction The benefits of clinical trials registration include improved transparency on clinical trials for healthcare workers and patients, increased accountability of trialists, the potential to address publication bias and selective reporting, and possibilities for research collaboration and prioritization. However, poor quality of information in registered records of...

The Quality of Registration of Clinical Trials

Background Lack of transparency in clinical trial conduct, publication bias and selective reporting bias are still important problems in medical research. Through clinical trials registration, it should be possible to take steps towards resolving some of these problems. However, previous evaluations of registered records of clinical trials have shown that registered information...

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

, Canada); Kay Dickersin, Johns Hopkins Bloomberg School of Public Health; Matthias Egger, Institut für Sozial-und Präventivmedizin; Davina Ghersi, National Health and Medical Research Council (Canberra

PROSPERO at one year: an evaluation of its utility

Background PROSPERO, an international prospective register of systematic review protocols in health and social care, was launched in February 2011. After one year of operation we describe access and use, explore user experience and identify areas for future improvement. Methods We collated administrative data and web statistics and conducted an online survey of users’ experiences...

The nuts and bolts of PROSPERO: an international prospective register of systematic reviews

Systematic Reviews The nuts and bolts prospective register Booth et al. Alison Booth Mike Clarke Gordon Dooley Davina Ghersi David Moher Mark Petticrew Lesley Stewart - of PROSPERO: an

Establishing a Minimum Dataset for Prospective Registration of Systematic Reviews: An International Consultation

Background In response to growing recognition of the value of prospective registration of systematic review protocols, we planned to develop a web-based open access international register. In order for the register to fulfil its aims of reducing unplanned duplication, reducing publication bias, and providing greater transparency, it was important to ensure the appropriate data...

Guidance for Evidence-Informed Policies about Health Systems: Assessing How Much Confidence to Place in the Research Evidence

In the third paper in a three-part series on health systems guidance, Simon Lewin and colleagues explore the challenge of assessing how much confidence to place in evidence on health systems interventions.

Practical methods for incorporating summary time-to-event data into meta-analysis

Background In systematic reviews and meta-analyses, time-to-event outcomes are most appropriately analysed using hazard ratios (HRs). In the absence of individual patient data (IPD), methods are available to obtain HRs and/or associated statistics by carefully manipulating published or other summary data. Awareness and adoption of these methods is somewhat limited, perhaps...

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

Elm Carrol Gamble Davina Ghersi John P. A. Ioannidis John Simes Paula R. Williamson Nandi Siegfried, Medical Research Council South Africa, South Africa Background: The increased use of meta-analysis