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Expression profiling of cell-intrinsic regulators in the process of differentiation of human iPSCs into retinal lineages

BackgroundDifferentiation of human induced pluripotent stem cells (hiPSCs) into retinal lineages offers great potential for medical application. Therefore, it is of crucial importance to know the key intrinsic regulators of differentiation and the specific biomarker signatures of cell lineages.MethodsIn this study, we used microarrays to analyze transcriptomes of terminally...

Protective effect of metformin against retinal vein occlusions in diabetes mellitus – A nationwide population-based study

specific funding for this work. The authors would like to thank the National Health Research Institutes for supplying data. Author Contributions Conceptualization: Tai-Chi Lin, De-Kuang Hwang, Chih-Chien ... Hsu. Data curation: De-Kuang Hwang, Chih-Chien Hsu, Mong-Lien Wang. Formal analysis: De-Kuang Hwang, Mong-Lien Wang. Investigation: Tai-Chi Lin, De-Kuang Hwang, Mong-Lien Wang, Shih-Jen Chen

Impact of Socioeconomic Status on the Diagnosis of Primary Open-Angle Glaucoma and Primary Angle Closure Glaucoma: A Nationwide Population-Based Study in Taiwan

Purpose To understand the impact of socioeconomic status (SES) on the diagnosis of primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG) in Taiwan. Methods Subjects with glaucoma were identified from the National Health Insurance Research Database of year 2006, which included one million randomly selected insurants. Individuals who had ≥4 ambulatory visits...

Increased Risk of Acute Angle Closure in Retinitis Pigmentosa: A Population-Based Case-Control Study

Purpose To investigate the association between retinitis pigmentosa (RP) and acute angle closure during a 15-year follow-up period. Methods Using the Taiwan Longitudinal Health Insurance Database 2000, we identified 382 RP patients based on the diagnostic code of RP (International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) 362.74) made during 1996...

Risk Factors for Progressive Visual Field Loss in Primary Angle-Closure Glaucoma: A Retrospective Cohort Study

PurposeTo investigate risk factors associated with progressive visual field (VF) loss in primary angle closure glaucoma (PACG). MethodsWe retrospectively reviewed medical record of PACG patients who had ≥5 reliable VF examinations (central 24-2 threshold test, Humphrey Field Analyzer) and ≥2 years of follow-up. Each VF was scored using Collaborative Initial Glaucoma Treatment...