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Differences in pathogenicity of three animal isolates of Mycobacterium species in a mouse model

: GDT20161100071). Author Contributions Conceptualization: Haodi Dong, Yue Lv, Xiangmei Zhou. Data curation: Haodi Dong, Yue Lv. Formal analysis: Haodi Dong, Yue Lv. Funding acquisition: Deming Zhao, Xiangmei ... Zhou. Investigation: Haodi Dong, Yue Lv. Methodology: Haodi Dong, Xiangmei Zhou. Project administration: Haodi Dong, Xiangmei Zhou. Resources: Deming Zhao, Xiangmei Zhou. Software: Haodi Dong, Yue

The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection

Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne’s disease of domestic and wild ruminants. Johne’s disease is characterized by chronic granulomatous enteritis leading to substantial economic losses to the livestock sector across the world. MAP persistently survives in phagocytic cells, most commonly in macrophages by ...

Evaluating the effects of land use and cover change on the decrease of surface wind speed over China in recent 30 years using a statistical downscaling method

The long-term decrease of surface wind speed (SWS) has been revealed by previous studies in China in recent decades, but the reasons for the SWS decrease remain uncertain. In this paper, we evaluated the effects of land use and cover change (LUCC) on the SWS decrease during 1980–2011 over the Eastern China Plain (ECP) region using a combined method of statistical downscaling and ...

Virulent Mycobacterium bovis Beijing Strain Activates the NLRP7 Inflammasome in THP-1 Macrophages

Mycobacterium bovis is the causative agent of tuberculosis in a wide range of mammals, including humans. Macrophages are the first line of host defense. They secrete proinflammatory cytokines, such as interleukin-1 beta (IL-1β), in response to mycobacterial infection, but the underlying mechanisms by which human macrophages are activated and release IL-1β following M. bovis ...

The Cellular Prion Protein Negatively Regulates Phagocytosis and Cytokine Expression in Murine Bone Marrow-Derived Macrophages

The cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein on the cell surface. Previous studies have demonstrated contradictory roles for PrPC in connection with the phagocytic ability of macrophages. In the present work, we investigated the function of PrPC in phagocytosis and cytokine expression in bone marrow-derived macrophages infected ...

The AIM2 Inflammasome Is Involved in Macrophage Activation During Infection With Virulent Mycobacterium bovis Strain

Background. Mycobacterium bovis, the causative agent of bovine tuberculosis, infects host macrophages and triggers production of the proinflammatory cytokine interleukin 1β (IL-1β). The mechanism by which macrophages become activated and secrete IL-1β in tuberculosis has not yet been elucidated. Methods. In this study, we investigated the role of the absence in melanoma 2 (AIM2) ...

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

Zhou Xiaomin Yin Deming Zhao 0 Equal contributors State Key Laboratories for Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible

CD36 Participates in PrP106–126-Induced Activation of Microglia

Microglial activation is a characteristic feature of the pathogenesis of prion diseases. The molecular mechanisms that underlie prion-induced microglial activation are not very well understood. In the present study, we investigated the role of the class B scavenger receptor CD36 in microglial activation induced by neurotoxic prion protein (PrP) fragment 106–126 (PrP106–126). We ...

PrPSc-Specific Antibodies with the Ability to Immunodetect Prion Oligomers

The development of antibodies with binding capacity towards soluble oligomeric forms of PrPSc recognised in the aggregation process in early stage of the disease would be of paramount importance in diagnosing prion diseases before extensive neuropathology has ensued. As blood transfusion appears to be efficient in the transmission of the infectious prion agent, there is an urgent ...