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A New Calibration Method for the Real-Time Calculation of Dynamic Safety Following Distance under Railway Moving Block System

3National Institute of Clean-and-Low-Carbon Energy, Beijing 102211, China Correspondence should be addressed to Deng Pan; nc.ude.ijgnot@gnednap Received 23 February 2018; Revised 26 July 2018; Accepted 30 ... July 2018; Published 12 August 2018 Academic Editor: Yongheng Yang Copyright © 2018 Deng Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which

Gravitational field around black hole induces photonic spin–orbit interaction that twists light

The spin–orbit interaction (SOI) of light has been intensively studied in nanophotonics because it enables sensitive control of photons’ spin degree of freedom and thereby the trajectories of the photons, which is useful for applications such as signal encoding and routing. A recent study [Phys. Rev. Lett. 117, 166803 (2016)] showed that the SOI of photons manifests in the...

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

irradiation. FOOTNOTES This work was partially supported by grants from National Natural Science Foundation of China (Grant Nos. 31670904 and 81502460 to X.Z., and 81570211 to X.L). Shilei Zhang, Deng Pan

Role of BmDredd during Apoptosis of Silk Gland in Silkworm, Bombyx mori

Silk glands (SGs) undergo massive apoptosis driven degeneration during the larval-pupal transformation. To better understand this event on molecular level, we investigated the expression of apoptosis-related genes across the developmental transition period that spans day 4 in the fifth instar Bombyx mori larvae to day 2 pupae. Increases in the expression of BmDredd (an initiator...

Cestrum nocturnum Flower Extracts Attenuate Proliferation and Induce Apoptosis in Malignant Cells through Inducing DNA Damage and Inhibiting Topoisomerase II Activity

: Ciara Hughes Copyright © 2017 Deng-Pan Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction ... interests. Authors’ Contributions Deng-Pan Wu, Tian-Yu Lin, and Jin-Yan Lv contributed equally to this project. Acknowledgments This project was supported by the Natural Science Foundation of China (nos

Selective DNA Delivery to Tumor Cells Using an Oligoarginine-LTVSPWY Peptide

DNA therapy for cancer requires efficient, selective and safe DNA delivery systems. Compared with other non-viral methods such as lipid or polymer-based DNA delivery vectors, peptide-based DNA delivery systems are biocompatible and biodegradable, which leads to lower immunogenicity and lower toxicity. Moreover, peptide vectors are easier to produce and their compositions easier...

An Atlas of the Speed of Copy Number Changes in Animal Gene Families and Its Implications

The notion that gene duplications generating new genes and functions is commonly accepted in evolutionary biology. However, this assumption is more speculative from theory rather than well proven in genome-wide studies. Here, we generated an atlas of the rate of copy number changes (CNCs) in all the gene families of ten animal genomes. We grouped the gene families with similar...

Burst of Young Retrogenes and Independent Retrogene Formation in Mammals

Retroposition and retrogenes gain increasing attention as recent studies show that they play an important role in human new gene formation. Here we examined the patterns of retrogene distribution in 8 mammalian genomes using 4 non-mammalian genomes as a contrast. There has been a burst of young retrogenes not only in primate lineages as suggested in a recent study, but also in...

Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro

Background Optimization of the unsaturated fatty acid composition of ruminant milk and meat is desirable. Alteration of the milk and fatty acid profile was previously attempted by the management of ruminal microbial biohydrogenation. The aim of this study was to identify the group of ruminal trans-vaccenic acid (trans-11 C18:1, t-VA) hydrogenating bacteria by combining enrichment...

Antidiabetic, Antihyperlipidemic and Antioxidant Activities of a Novel Proteoglycan from Ganoderma Lucidum Fruiting Bodies on db/db Mice and the Possible Mechanism

Previously, we screened a proteoglycan for anti-hyperglycemic, named FYGL, from Ganoderma Lucidum. For further research of the antidiabetic mechanisms of FYGL in vivo, the glucose homeostasis, activities of insulin-sensitive enzymes, glucose transporter expression and pancreatic function were analyzed using db/db mice as diabetic models in the present work. FYGL not only lead to...

Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates

duplication rates Deng Pan and Liqing Zhang 0 Address: Department of Computer Science, Virginia Tech , Torgerson Hall, Blacksburg, Virginia 24061-0106 , USA Background: The rate of gene duplication is an

Genome-wide profiling of polyadenylation sites reveals a link between selective polyadenylation and cancer metastasis

Alternative polyadenylation (APA) is an important post-transcriptional modification implicated in many diseases, including cancer. Although extensively characterized, the functional consequence of APA modulation on tumorigenesis remains elusive. Here, we developed a deep sequencing-based approach that specifically profiles 3′ termini of polyadenylated RNAs (herein termed 3T-seq...

DGIdb 2.0: mining clinically relevant drug–gene interactions

The Drug–Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that consolidates disparate data sources describing drug–gene interactions and gene druggability. It provides an intuitive graphical user interface and a documented application programming interface (API) for querying these data. DGIdb was assembled through an extensive manual curation effort, reflecting...

N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation

Elevated expression and activity of N-acetylglucosaminyltransferase V (Mgat5) in hepatocellular carcinoma (HCC) is a common early event involved in tumor invasion during hepatocarcinogenesis. A better understanding of the functional role and the molecular mechanism for Mgat5-targeted protein and downstream signaling pathway behind hepatoma invasion and metastasis is urgently...

Klotho Endows Hepatoma Cells with Resistance to Anoikis via VEGFR2/PAK1 Activation in Hepatocellular Carcinoma

Klotho was originally characterized as an aging suppressor gene that predisposed Klotho-deficient mice to premature aging-like syndrome. Although Klotho was recently reported to exhibit tumor suppressive properties during various malignant transformations, the functional role and molecular mechanism of Klotho in hepatocarcinogenesis remains poorly understood. In our present study...