und Poliklinik der Technischen Universität München, Ismaningerstr. 22, 81675, Munich, Germany Dieter Saur & Barbara Seidler AuthorsLinlin Zhao View author publications You can also search for this ... this author in PubMed Google Scholar Xiaogang Zhao View author publications You can also search for this author in PubMed Google Scholar Dieter Saur View author publications You can also search
München, München, GermanyGünter Schneider, Dieter Saur & Heiko LickertGerman Center for Diabetes Research (DZD), GermanyHeiko LickertGerman Cancer Consortium (DKTK), Heidelberg, GermanyDieter SaurGerman ... for Arie Geerlof in:Nature Research journals • PubMed • Google ScholarSearch for Günter Schneider in:Nature Research journals • PubMed • Google ScholarSearch for Dieter Saur in:Nature Research journals
Martina Brandl Barbara Seidler Ferdinand Haller Jerzy Adamski Roland M. Schmid Dieter Saur Gu nter Schneider In Fig. 4A, the cRel siRNA western blot panel was inadvertently constructed using the
Proper functioning of the lymphatic system is required for normal immune responses, fluid balance, and lipid reabsorption. Multiple regulatory mechanisms are employed to ensure the correct formation and function of lymphatic vessels; however, the epigenetic modulators and mechanisms involved in this process are poorly understood. Here, we assess the regulatory role of mouse Dot1l...
We are extending the Cre/loxP site-specific recombination system to pigs, focussing on conditional and tissue-specific expression of oncogenic mutations to model human cancers. Identifying the location, pattern and extent of Cre recombination in vivo is an important aspect of this technology. Here we report pigs with a dual fluorochrome cassette under the control of the strong...
Alejandra Hernandez-Caceres Christine Wurmser Carolin Perleberg Hubert Pausch Anna Perkowska Konrad Fischer Dmitrij Frishman Ruedi Fries Marek Switonski Alexander Kind Dieter Saur Angelika Schnieke Krzysztof
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is less than 5% demonstrating the insufficiency of current therapies. Most cytotoxic therapies induce apoptosis and PDAC...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. Overall, the 5-year survival rate is less than 5% demonstrating the insufficiency of current therapies. Most cytotoxic therapies induce apoptosis and PDAC...
The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC warrants further clarification. We report here that a clinically relevant proteasome inhibitor significantly increases MYC protein levels and that endogenous MYC is necessary for the induction of apoptosis. This kind of MYC...
Martina Brandl Barbara Seidler Ferdinand Haller Jerzy Adamski Roland M. Schmid Dieter Saur Gu nter Schneider In Fig. 4A, the cRel siRNA western blot panel was inadvertently constructed using the
Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a well-defined volume. Though preliminary clinical results for IRE...
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a dismal prognosis and no effective conservative therapeutic strategies. Although it is demonstrated that histone deacetylases (HDACs), especially the class I HDACs HDAC1, 2 and 3 are highly expressed in this disease, little is known about HDAC isoenzyme specific functions. Results...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a dismal prognosis and no effective conservative therapeutic strategies. Although it is demonstrated that histone deacetylases (HDACs), especially the class I HDACs HDAC1, 2 and 3 are highly expressed in this disease, little is known about HDAC isoenzyme specific functions. Depletion of HDAC2, but...
Current methods of generating rat induced pluripotent stem cells are based on viral transduction of pluripotency inducing genes (Oct4, Sox2, c-myc and Klf4) into somatic cells. These activate endogenous pluripotency genes and reprogram the identity of the cell to an undifferentiated state. Epigenetic silencing of exogenous genes has to occur to allow normal iPS cell...
Saur 0 0 Department of Internal Medicine 2, Klinikum rechts der Isar, Technische Universitat Munchen , 81675 Munchen , Germany - From 6th International Conference on cGMP: Generators, Effectors and
